4-氨基-5-丁基-2-吡啶羧酸合成路线 （共 6 条）
反应条件
1: H2O2 / acetic acid
2: 24 percent / 65 percent HNO3, conc. H2SO4 / 3 h / 93 - 95 °C
3: 41 percent / 1 h / 120 - 130 °C
4: 68 percent / 10 percent HCl / 1.5 h / 80 °C
5: 86 percent / KMnO4, tetrabutylammoniumbromide / benzene; H2O / 1) 30 min, 5-10 deg C; 2) 30 min, 50 deg C
6: 19 percent / H2S, 25 percent NH3 / 2 h / Heating
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
1: 41 percent / 1 h / 120 - 130 °C
2: 68 percent / 10 percent HCl / 1.5 h / 80 °C
3: 86 percent / KMnO4, tetrabutylammoniumbromide / benzene; H2O / 1) 30 min, 5-10 deg C; 2) 30 min, 50 deg C
4: 19 percent / H2S, 25 percent NH3 / 2 h / Heating
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
1: 24 percent / 65 percent HNO3, conc. H2SO4 / 3 h / 93 - 95 °C
2: 41 percent / 1 h / 120 - 130 °C
3: 68 percent / 10 percent HCl / 1.5 h / 80 °C
4: 86 percent / KMnO4, tetrabutylammoniumbromide / benzene; H2O / 1) 30 min, 5-10 deg C; 2) 30 min, 50 deg C
5: 19 percent / H2S, 25 percent NH3 / 2 h / Heating
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
1: 86 percent / KMnO4, tetrabutylammoniumbromide / benzene; H2O / 1) 30 min, 5-10 deg C; 2) 30 min, 50 deg C
2: 19 percent / H2S, 25 percent NH3 / 2 h / Heating
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
1: 68 percent / 10 percent HCl / 1.5 h / 80 °C
2: 86 percent / KMnO4, tetrabutylammoniumbromide / benzene; H2O / 1) 30 min, 5-10 deg C; 2) 30 min, 50 deg C
3: 19 percent / H2S, 25 percent NH3 / 2 h / Heating
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
ammonium hydroxide; hydrogen sulfide
2 h; Heating;
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
