1: diisopropylethylamine / dimethylformamide / 18 h / 20 °C
2: 92 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 20.5 h / 20 °C
3: 90 percent / aqueous sodium hydroxide / dioxane / 19 h / 20 °C
View Scheme
参考文献
Harris, Paul W.R.; Brimble, Margaret A.; Muir, Victoria J.; Lai, Michelle Y.H.; Trotter, Nicholas S.; Callis, David J.
Tetrahedron, 2005 , vol. 61, # 42 p. 10018 - 10035
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.83 h / -78 °C
1.2: 63 percent / tetrahydrofuran / 2 h / -78 - -50 °C
2.1: 100 percent / thionyl chloride / 3 h / Heating
3.1: 92 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 20.5 h / 20 °C
4.1: 90 percent / aqueous sodium hydroxide / dioxane / 19 h / 20 °C
View Scheme
参考文献
Harris, Paul W.R.; Brimble, Margaret A.; Muir, Victoria J.; Lai, Michelle Y.H.; Trotter, Nicholas S.; Callis, David J.
Tetrahedron, 2005 , vol. 61, # 42 p. 10018 - 10035
1: 92 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 20.5 h / 20 °C
2: 90 percent / aqueous sodium hydroxide / dioxane / 19 h / 20 °C
View Scheme
参考文献
Harris, Paul W.R.; Brimble, Margaret A.; Muir, Victoria J.; Lai, Michelle Y.H.; Trotter, Nicholas S.; Callis, David J.
Tetrahedron, 2005 , vol. 61, # 42 p. 10018 - 10035
1: 100 percent / thionyl chloride / 3 h / Heating
2: 92 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 20.5 h / 20 °C
3: 90 percent / aqueous sodium hydroxide / dioxane / 19 h / 20 °C
View Scheme
参考文献
Harris, Paul W.R.; Brimble, Margaret A.; Muir, Victoria J.; Lai, Michelle Y.H.; Trotter, Nicholas S.; Callis, David J.
Tetrahedron, 2005 , vol. 61, # 42 p. 10018 - 10035
1.1: 77 percent / CHCl3 / 6 h / Heating
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.83 h / -78 °C
2.2: 63 percent / tetrahydrofuran / 2 h / -78 - -50 °C
3.1: 100 percent / thionyl chloride / 3 h / Heating
4.1: 92 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 20.5 h / 20 °C
5.1: 90 percent / aqueous sodium hydroxide / dioxane / 19 h / 20 °C
View Scheme
参考文献
Harris, Paul W.R.; Brimble, Margaret A.; Muir, Victoria J.; Lai, Michelle Y.H.; Trotter, Nicholas S.; Callis, David J.
Tetrahedron, 2005 , vol. 61, # 42 p. 10018 - 10035
