2-氯-3-甲基-3H-咪唑-4-羧酸合成路线 (共 2 条)
反应条件
1: 2-chloro-1-methyl-1H-imidazole With n-butyllithium in tetrahydrofuran; cyclohexane
T=-78°C; 1.16667 h;
2: carbon dioxide in tetrahydrofuran; cyclohexane
T=-78 - 20°C; 0.25 h;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
NEUROGEN CORPORATION
Patent: WO2006/89076 A2, 2006 ;
Location in patent: Page/Page column 44 ;
WO 2006/089076 A2
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 20°C;
2: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
Jones, Todd K.; Mani, Neelakandha
Patent: US2005/250948 A1, 2005 ;
Location in patent: Page/Page column 45 ;