二甲基哌啶-1,4-二羧酸合成路线 （共 3 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=0 - 20°C;
参考文献
Burns, David M.; Yao, Wenqing; He, Chunhong
Patent: US2005/250789 A1, 2005 ;
Location in patent: Page/Page column 43 ;
US 20050250789 A1
反应条件
1: dimethyl piperidin-1,4-dicarboxylate With lithium diisopropyl amide in tetrahydrofuran; hexane
0.5 h;
2: carbon dioxide in tetrahydrofuran; hexane
0.25 h;
参考文献
Mihovilovic, Marko D.; Fischer, Thomas C. M.; Stanetty, Peter
Molecules, 2006 , vol. 11, # 5 p. 357 - 364
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h
1.2: 84 percent / tetrahydrofuran; hexane / 0.25 h
2.1: 91 percent / thionyl chloride / CH2Cl2 / 144 h / 20 °C
View Scheme
参考文献
Mihovilovic, Marko D.; Fischer, Thomas C. M.; Stanetty, Peter
Molecules, 2006 , vol. 11, # 5 p. 357 - 364
