(4-氯-3-氟苯基)氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
iodine cloride; acetic acid
参考文献
Mayes, Benjamin A.; Chaudhuri, Narayan C.; Hencken, Christopher P.; Jeannot, Frederic; Latham, G. Mark; Mathieu, Steven; Mcgarry, F. Patrick; Stewart, Alistair J.; Wang, Jingyang; Moussa, Adel
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1248 - 1253
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2.67 h / -80 - -75 °C / Inert atmosphere 1.2: 17 h / -80 - -30 °C / Inert atmosphere 2.1: hydrogenchloride; water / ethanol / 2 h / 5 - 55 °C / Inert atmosphere 2.2: 1 h / 5 - 15 °C / Inert atmosphere View Scheme
参考文献
Mayes, Benjamin A.; Chaudhuri, Narayan C.; Hencken, Christopher P.; Jeannot, Frederic; Latham, G. Mark; Mathieu, Steven; Mcgarry, F. Patrick; Stewart, Alistair J.; Wang, Jingyang; Moussa, Adel
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1248 - 1253
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2.67 h / -80 - -75 °C / Inert atmosphere
1.2: 17 h / -80 - -30 °C / Inert atmosphere
2.1: hydrogenchloride; water / ethanol / 2 h / 5 - 55 °C / Inert atmosphere
2.2: 1 h / 5 - 15 °C / Inert atmosphere
3.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 20 - 36 °C / Inert atmosphere
3.2: 18 h / 20 - 100 °C / Inert atmosphere
View Scheme
参考文献
Mayes, Benjamin A.; Chaudhuri, Narayan C.; Hencken, Christopher P.; Jeannot, Frederic; Latham, G. Mark; Mathieu, Steven; Mcgarry, F. Patrick; Stewart, Alistair J.; Wang, Jingyang; Moussa, Adel
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1248 - 1253
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2.67 h / -80 - -75 °C / Inert atmosphere
1.2: 17 h / -80 - -30 °C / Inert atmosphere
2.1: hydrogenchloride; water / ethanol / 2 h / 5 - 55 °C / Inert atmosphere
2.2: 1 h / 5 - 15 °C / Inert atmosphere
3.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 20 - 36 °C / Inert atmosphere
3.2: 18 h / 20 - 100 °C / Inert atmosphere
4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 3 h / 20 - 25 °C / Inert atmosphere
4.2: 3 h / 20 - 25 °C / Inert atmosphere
View Scheme
参考文献
Mayes, Benjamin A.; Chaudhuri, Narayan C.; Hencken, Christopher P.; Jeannot, Frederic; Latham, G. Mark; Mathieu, Steven; Mcgarry, F. Patrick; Stewart, Alistair J.; Wang, Jingyang; Moussa, Adel
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1248 - 1253
