4-甲基-1-[4-(三氟甲基)苯基]-1-戊酮合成路线 （共 2 条）
反应条件
1: magnesium; 1-bromo-3-methyl-butane in tetrahydrofuran
T=20 - 35°C; 1.25 h;
2: p-(trifluoromethyl)-benzonitrile With copper(I) bromide in tetrahydrofuran; toluene
T=25°C; 1 h;
3: With sulfuric acid in tetrahydrofuran; water; toluene
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2005/108362 A1, 2005 ;
Location in patent: Page/Page column 31 ;
WO 2005/108362 A1
反应条件
1: 1-bromo-3-methyl-butane With magnesium in tetrahydrofuran
T=20 - 35°C; 1 h;
2: p-(trifluoromethyl)-benzonitrile With copper(I) bromide in tetrahydrofuran; toluene
T=25°C; 1 h;
3: With sulfuric acid; water in tetrahydrofuran; toluene
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2007/54739 A1, 2007 ;
Location in patent: Page/Page column 18 ;
WO 2007/054739 A1
