3,6-二甲基-咪唑并[2,1-b]噻唑-5-羧酸乙酯合成路线 （共 3 条）
反应条件
1: in ethanol
2.5 h; Heating / reflux;
2: With trichlorophosphate in acetonitrile
60 h; Heating / reflux;
3: With sodium carbonate in chloroform; water
T=0°C;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/16560 A2, 2009 ;
Location in patent: Page/Page column 77 ;
WO 2009/016560 A2
反应条件
in ethanol
8 h; Heating;
参考文献
Abignente, E.; Caprariis, P. De; Sacchi, A.; Marmo, E.; Berrino, L.; Matera, M. G.
Farmaco, Edizione Scientifica, 1983 , vol. 38, # 7 p. 533 - 545
反应条件
ethanol
Erwaermen des entstandenen 2-Acetonylmercapto-5-methyl-1(3)H-imidazol-4-carbonsaeure-aethylester mit POCl3;
参考文献
Ochiai
Chemische Berichte, 1936 , vol. 69, p. 1650,1652
