6-氯-4-硝基-1-[[2-(三甲基甲硅烷基)乙氧基]甲基]-1H-吡咯并[2,3-b]吡啶合成路线 （共 3 条）
反应条件
1: 6-chloro-4-nitro-1H-pyrrolo[2,3-b]pyridine With sodium hydride in DMF (N,N-dimethyl-formamide)
T=0°C; 0.5 h;
2: trimethylsilyl ethoxymethyl chloride in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 2 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/108397 A1, 2005 ;
Location in patent: Page/Page column 29 ;
反应条件
1: Cl3CCOCl; (Me3Si)2NH / tetrahydrofuran / 1 h
2: 65 percent / NaH / tetrahydrofuran / 1 h
View Scheme
参考文献
Figueroa-Perez, Santiago; Bennabi, Samir; Schirok, Hartmut; Thutewohl, Michael
Tetrahedron Letters, 2006 , vol. 47, # 13 p. 2069 - 2072
反应条件
1.1: 88 percent / K2CO3 / dimethylsulfoxide / 2 h / 100 °C
2.1: 92 percent / H2 / Pd/C / ethanol / 24 h / 20 °C
3.1: TFA / CH2Cl2 / 2 h / 20 °C
3.2: 79 percent / AcONa / ethanol / 1 h
View Scheme
参考文献
Figueroa-Perez, Santiago; Bennabi, Samir; Schirok, Hartmut; Thutewohl, Michael
Tetrahedron Letters, 2006 , vol. 47, # 13 p. 2069 - 2072
