S4-(2-氰基乙基)-4-硫代胸腺嘧啶脱氧核苷合成路线 （共 4 条）
反应条件
pyridine T=20°C; 2 h;
参考文献
Yamada, Kenji; Hattori, Yusaku; Inde, Takeshi; Kanamori, Takashi; Ohkubo, Akihiro; Seio, Kohji; Sekine, Mitsuo
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 776 - 778
反应条件
triethylamine tris(hydrogen fluoride); triethylamine in tetrahydrofuran
T=20°C; 14 h;
参考文献
Yamada, Kenji; Hattori, Yusaku; Inde, Takeshi; Kanamori, Takashi; Ohkubo, Akihiro; Seio, Kohji; Sekine, Mitsuo
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 776 - 778
反应条件
1.1: tetrabutylammomium bromide; sodium carbonate / dichloromethane / 12 h / 20 °C
2.1: N-methyl-pyrrolidine / dichloromethane / 1 h / 0 °C
2.2: 1 h / 0 °C
3.1: triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 14 h / 20 °C
View Scheme
参考文献
Yamada, Kenji; Hattori, Yusaku; Inde, Takeshi; Kanamori, Takashi; Ohkubo, Akihiro; Seio, Kohji; Sekine, Mitsuo
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 776 - 778
反应条件
1.1: N-methyl-pyrrolidine / dichloromethane / 1 h / 0 °C
1.2: 1 h / 0 °C
2.1: triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 14 h / 20 °C
View Scheme
参考文献
Yamada, Kenji; Hattori, Yusaku; Inde, Takeshi; Kanamori, Takashi; Ohkubo, Akihiro; Seio, Kohji; Sekine, Mitsuo
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 776 - 778
