4-[[9-氯-7-(2,6-二氟苯基)-5H-嘧啶并[5,4-d][2]苯并氮杂卓-2-基]氨基]苯甲酸合成路线 （共 8 条）
反应条件
potassium carbonate in ethanol 14 h; Inert atmosphereReflux;
参考文献
Yang, Katherine S.; Budin, Ghyslain; Reiner, Thomas; Vinegoni, Claudio; Weissleder, Ralph
Angewandte Chemie - International Edition, 2012 , vol. 51, # 27 p. 6598 - 6603
反应条件
1: sulfuric acid / dichloromethane / 0 °C / Inert atmosphere 2: toluene / 4 h / 80 °C / Inert atmosphere 3: potassium carbonate / ethanol / 14 h / Inert atmosphere; Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 27 p. 6598 - 6603
反应条件
1: toluene / 4 h / 80 °C / Inert atmosphere 2: potassium carbonate / ethanol / 14 h / Inert atmosphere; Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 27 p. 6598 - 6603
反应条件
1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere 2.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0 - 5 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.5 h / Inert atmosphere 3.2: 16 h / 20 °C / Inert atmosphere 4.1: sulfuric acid / dichloromethane / 0 °C / Inert atmosphere 5.1: toluene / 4 h / 80 °C / Inert atmosphere 6.1: potassium carbonate / ethanol / 14 h / Inert atmosphere; Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 27 p. 6598 - 6603
反应条件
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.5 h / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: sulfuric acid / dichloromethane / 0 °C / Inert atmosphere 3.1: toluene / 4 h / 80 °C / Inert atmosphere 4.1: potassium carbonate / ethanol / 14 h / Inert atmosphere; Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 27 p. 6598 - 6603
反应条件
1.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0 - 5 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.5 h / Inert atmosphere 2.2: 16 h / 20 °C / Inert atmosphere 3.1: sulfuric acid / dichloromethane / 0 °C / Inert atmosphere 4.1: toluene / 4 h / 80 °C / Inert atmosphere 5.1: potassium carbonate / ethanol / 14 h / Inert atmosphere; Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 27 p. 6598 - 6603
反应条件
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 3.33 h / -78 - -30 °C / Inert atmosphere 1.2: 0.83 h / -78 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere 3.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0 - 5 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.5 h / Inert atmosphere 4.2: 16 h / 20 °C / Inert atmosphere 5.1: sulfuric acid / dichloromethane / 0 °C / Inert atmosphere 6.1: toluene / 4 h / 80 °C / Inert atmosphere 7.1: potassium carbonate / ethanol / 14 h / Inert atmosphere; Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 27 p. 6598 - 6603
反应条件
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 3.33 h / -78 - -30 °C / Inert atmosphere 1.2: 0.83 h / -78 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere 3.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0 - 5 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.5 h / Inert atmosphere 4.2: 16 h / 20 °C / Inert atmosphere 5.1: sulfuric acid / dichloromethane / 0 °C / Inert atmosphere 6.1: toluene / 4 h / 80 °C / Inert atmosphere 7.1: potassium carbonate / ethanol / 14 h / Inert atmosphere; Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 27 p. 6598 - 6603
