(5-氯-2-碘苯基) 2,6-二氟苯甲烷合成路线 （共 11 条）
反应条件
1.1: tert-butyl methyl ether; methanol / 3.5 h / 25 - 30 °C
2.1: diethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / cyclohexane / 15 h / 28 - 33 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane; water / 20 h / 20 - 35 °C
3.2: 2.5 h / 20 - 30 °C / pH 8
3.3: 20.5 h / 20 - 42 °C
View Scheme
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; ARMITAGE, Ian; COOPER, Martin, I.; EDDLESTON, Mark, D.; FAIBER, Neil, C.; MCCUBBIN, Quentin, J.; WATT, Stephen, W.
Patent: WO2011/103089 A1, 2011 ;
WO 2011/103089 A1
