1-苄基-4-氰甲基哌啶-4-甲腈合成路线 （共 14 条）
反应条件
in ethanol; water 4.5 h; Heating;
参考文献
New, J. S.; Yevich, J. P.
Synthesis, 1983 , # 5 p. 388 - 389
反应条件
water in ethanol T=20 - 65°C; 24 h;
参考文献
WO2004/69256 A1, ;
Page/Page column 41 ;
WO 2004/069256 A1
反应条件
in ethanol; water T=65°C; 24 h;
参考文献
WO2009/117728 A2, ;
Page/Page column 62 ;
反应条件
1: Et3N; molecular sieves 4A / CH2Cl2 / 20 °C 2: 55.10 g / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2037 - 2061
反应条件
1.1: conc. aq. HCl / 24 h / Heating 2.1: SOCl2 3.1: DIEA / acetonitrile / 20 °C 3.2: NaOAc; Ac2O / Heating 4.1: BH3 / tetrahydrofuran / Heating 5.1: CAN / acetonitrile; H2O View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: conc. aq. HCl / 24 h / Heating 2.1: SOCl2 3.1: DIEA / acetonitrile / 20 °C 3.2: NaOAc; Ac2O / Heating 4.1: BH3 / tetrahydrofuran / Heating 5.1: CAN / acetonitrile; H2O 6.1: NaOH / dioxane View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: conc. aq. HCl / 24 h / Heating 2.1: SOCl2 3.1: DIEA / acetonitrile / 20 °C 3.2: NaOAc; Ac2O / Heating 4.1: BH3 / tetrahydrofuran / Heating 5.1: CAN / acetonitrile; H2O 6.1: NaOH / dioxane 7.1: H2 / Pd(OH)2/C / methanol / 5171.48 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 0.25 h; Heating;
参考文献
Synthesis, , # 5 p. 388 - 389
反应条件
sulfuric acid; acetic acid T=20 - 125°C; 1 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/76455 A1, 2004 ;
Location in patent: Page 18; 34 ;
WO 2004/076455 A1
反应条件
1.1: conc. aq. HCl / 24 h / Heating 2.1: SOCl2 3.1: DIEA / acetonitrile / 20 °C 3.2: NaOAc; Ac2O / Heating View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
