2,6-二氟-3-氰基吡啶合成路线 (共 2 条)
反应条件
1: 2,6-di-fluoro-pyridine With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 2 h; Cooling with acetone-dry ice;
2: 4-methylphenylcyanate in tetrahydrofuran
T=-78°C; 0.666667 h; Cooling with acetone-dry ice;
参考文献
ASTRAZENECA AB
Patent: WO2005/111001 A1, 2005 ;
Location in patent: Page/Page column 55 ;
WO 2005/111001 A1
反应条件
ammonium hydroxide in water
T=88°C; 12 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/111001 A1, 2005 ;
Location in patent: Page/Page column 55 ;
WO 2005/111001 A1