2-氨基-3-溴-5-氟吡啶合成路线 (共 4 条)
反应条件
N-bromosuccinmide in acetonitrile T=20°C;
参考文献
AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2011/143365 A1, 2011 ;
Location in patent: Page/Page column 154 ;
WO 2011/143365 A1
反应条件
1: With pyridine; hydrogen fluoride; sodium nitrite T=0 - 50°C; 1.5 h; polyethylene reaction vessel; 2: With sodium carbonate in water
参考文献
AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa
Patent: WO2011/143366 A1, 2011 ;
Location in patent: Page/Page column 75 ;
WO 2011/143366 A1
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) in DMF (N,N-dimethyl-formamide)
T=120°C; 0.666667 h; Microwave heating;
参考文献
ASTRAZENECA AB
Patent: WO2005/111001 A1, 2005 ;
Location in patent: Page/Page column 59 ;
WO 2005/111001 A1
反应条件
1: in 1-methyl-pyrrolidin-2-one
T=150°C; 5 h;
2: With ammonia in 1-methyl-pyrrolidin-2-one; water
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2248423 A1, 2010 ;
Location in patent: Page/Page column 272-273 ;