Boc-L-4-溴苯丙氨腈合成路线 （共 5 条）
反应条件
1: thionyl chloride / Reflux
2: sodium hydrogencarbonate / acetone / 20 °C
3: ammonia; methanol / 0.25 h / -50 - 20 °C
4: triethylamine; trifluoroacetic anhydride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
WO 2012/119941 A1
反应条件
1: water; methanol / 16 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
3: ammonia; methanol / 0.25 h / -50 - 20 °C
4: triethylamine; trifluoroacetic anhydride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
WO 2012/119941 A1
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
2: ammonia; methanol / 0.25 h / -50 - 20 °C
3: triethylamine; trifluoroacetic anhydride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
WO 2012/119941 A1
反应条件
1: sodium hydrogencarbonate / acetone / 20 °C
2: ammonia; methanol / 0.25 h / -50 - 20 °C
3: triethylamine; trifluoroacetic anhydride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
WO 2012/119941 A1
反应条件
1: ammonia; methanol / 0.25 h / -50 - 20 °C
2: triethylamine; trifluoroacetic anhydride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
WO 2012/119941 A1
