(3R)-3,4-吗啉二羧酸 4-叔丁酯合成路线 （共 5 条）
反应条件
sodium hydrogen sulphate in isopropanol acetate; water T=0 - 25°C; pH=3.0 - 3.5;
参考文献
WO2010/15626 A1, ;
Page/Page column 22-23 ;
WO 2010/015626 A1
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hydrogencarbonate; potassium bromide in acetone T=0°C; 2 h;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 3 p. 388 - 401
反应条件
1: 97 percent / Et3N / methanol / 1 h / 20 °C 2: 83 percent / aq. NaHCO3; TEMPO; NaOCl / KBr / acetone / 2 h / 0 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 17, # 3 p. 388 - 401
反应条件
1: 87 percent / TBAF / tetrahydrofuran 2: 97 percent / Et3N / methanol / 1 h / 20 °C 3: 83 percent / aq. NaHCO3; TEMPO; NaOCl / KBr / acetone / 2 h / 0 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 17, # 3 p. 388 - 401
反应条件
1: With tetrahydrofuran; borane T=0 - 20°C; 4.25 h; 2: With water; acetic acid in tetrahydrofuran 1 h; 3: With sodium hydrogencarbonate in tetrahydrofuran; water
参考文献
ICOS CORPORATION
Patent: WO2006/105262 A1, 2006 ;
Location in patent: Page/Page column 70 ;
