2-(1-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-2,3-二氢-1H-茚-5-基)-1,3-噻唑合成路线 (共 2 条)
反应条件
1: 2-bromo-1,3-thiazole With chloro-trimethyl-silane; ethylene dibromide; zinc in tetrahydrofuran
0.25 h;
2: [(5-bromo-2,3-dihydro-1H-inden-1-yl)oxy](tert-butyl)dimethylsilane With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
24 h; Heating / reflux;
参考文献
Xue, Chu-Biao; Cao, Ganfeng; Huang, Taisheng; Chen, Lihua; Zhang, Ke; Wang, Anlai; Meloni, David; Anand, Rajan; Glenn, Joseph; Metcalf, Brian W.
Patent: US2005/261310 A1, 2005 ;
Location in patent: Page/Page column 35 ;
US 20050261310 A1
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=0 - 20°C; 1 h;
参考文献
Xue, Chu-Biao; Cao, Ganfeng; Huang, Taisheng; Chen, Lihua; Zhang, Ke; Wang, Anlai; Meloni, David; Anand, Rajan; Glenn, Joseph; Metcalf, Brian W.
Patent: US2005/261310 A1, 2005 ;
Location in patent: Page/Page column 35 ;
US 20050261310 A1