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乙二醇
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63148-62-9
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碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
熊果酸苄酯
合成路线
(共 5 条)
869788-71-6
熊果酸苄酯
→
反应条件
4547-24-4
科罗索酸
反应条件
1.1: 91 percent / H2SO4 / 100 °C 2.1: BH3*THF 2.2: 55 percent / aq. NaOH; H2O2 3.1: 100 percent / H2 / Pd/C / tetrahydrofuran / 20 °C View Scheme
参考文献
Wen, Xiaoan; Sun, Hongbin; Liu, Jun; Wu, Guanzhong; Zhang, Luyong; Wu, Xiaoming; Ni, Peizhou
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4944 - 4948
192211-41-9
乌索酸苄酯
→
反应条件
869788-71-6
熊果酸苄酯
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78 - -50°C; Swern Oxidation; 0.25 h; Inert atmosphere; 2: With triethylamine in dichloromethane T=-50 - 20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; REGUEIRO-REN, Alicia; LIU, Zheng; SWIDORSKI, Jacob; MEANWELL, Nicholas A.; SIT, Sing-Yuen; CHEN, Jie; CHEN, Yan; SIN, Ny
Patent: WO2011/153319 A1, 2011 ;
Location in patent: Page/Page column 246; 247 ;
94482-51-6
+
100-39-0
溴化苄
→
反应条件
869788-71-6
熊果酸苄酯
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Sequoia Sciences, Inc.; Eldridge, Gary R.; Buckle, Ronald Neil; Ellis, Michael; Huang, Zhongping; Reilly, John Edward
Patent: EP2712863 A1, 2014 ;
Location in patent: Paragraph 0060 ;
77-52-1
→
反应条件
869788-71-6
熊果酸苄酯
反应条件
1: 96 percent / K2CO3 / dimethylformamide / 2 h / 85 °C 2: 89 percent / PCC / CH2Cl2 / 24 h / 0 °C View Scheme
参考文献
Wen, Xiaoan; Sun, Hongbin; Liu, Jun; Wu, Guanzhong; Zhang, Luyong; Wu, Xiaoming; Ni, Peizhou
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4944 - 4948
100-44-7
苄基氯
→
反应条件
869788-71-6
熊果酸苄酯
反应条件
1: 96 percent / K2CO3 / dimethylformamide / 2 h / 85 °C 2: 89 percent / PCC / CH2Cl2 / 24 h / 0 °C View Scheme
参考文献
Wen, Xiaoan; Sun, Hongbin; Liu, Jun; Wu, Guanzhong; Zhang, Luyong; Wu, Xiaoming; Ni, Peizhou
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4944 - 4948