4-二甲基氨基-7-(4-乙基-苯基)-7H-9-硫-1,5,7-三氮杂芴-8-酮合成路线 （共 5 条）
反应条件
toluene-4-sulfonic acid in toluene
T=130°C;
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Kolasa, Teodozyj; Patel, Meena; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Baker, Scott; Lehto, Sonya G.; Honore, Prisca; Wetter, Jill M.; Marsh, Kennan C.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4936 - 4940
反应条件
1: 99 percent / 5 h / Heating
2: 73 percent / p-TsOH / toluene
View Scheme
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Kolasa, Teodozyj; Patel, Meena; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Baker, Scott; Lehto, Sonya G.; Honore, Prisca; Wetter, Jill M.; Marsh, Kennan C.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4936 - 4940
反应条件
1.1: 93 percent / 1.33 h / 100 °C
2.1: 98 percent / HCl(gas) / methanol / 10 h / 0 °C
3.1: NaH / tetrahydrofuran / 0 °C
3.2: tetrahydrofuran / 24 h / 20 °C
3.3: 85 percent / NaH / tetrahydrofuran / 1.83 h / Heating
4.1: 99 percent / ethanol / 4.5 h / Heating
5.1: 73 percent / p-toluenesulfonic acid / toluene / 130 °C
View Scheme
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Nakane, Masaki; Lehto, Sonya G.; Honore, Marie P.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7374 - 7388
反应条件
1.1: 98 percent / HCl(gas) / methanol / 10 h / 0 °C
2.1: NaH / tetrahydrofuran / 0 °C
2.2: tetrahydrofuran / 24 h / 20 °C
2.3: 85 percent / NaH / tetrahydrofuran / 1.83 h / Heating
3.1: 99 percent / ethanol / 4.5 h / Heating
4.1: 73 percent / p-toluenesulfonic acid / toluene / 130 °C
View Scheme
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Nakane, Masaki; Lehto, Sonya G.; Honore, Marie P.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7374 - 7388
反应条件
1.1: NaH / tetrahydrofuran / 0 °C
1.2: tetrahydrofuran / 24 h / 20 °C
1.3: 85 percent / NaH / tetrahydrofuran / 1.83 h / Heating
2.1: 99 percent / ethanol / 4.5 h / Heating
3.1: 73 percent / p-toluenesulfonic acid / toluene / 130 °C
View Scheme
参考文献
Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan; Nakane, Masaki; Lehto, Sonya G.; Honore, Marie P.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7374 - 7388
