triethylamine in dichloromethane T=-25 - 0°C; 1.08333 - 1.16667 h;

1: (2α,3aβ,7aβ)-octahydro-1H-indole-2-carboxylic acid With chloro-trimethyl-silane; triethylamine in dichloromethane T=20 - 25°C; 2 h; 2: N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride in dichloromethane T=-15 - 0°C; 2 h; 3: With sodium hydroxide in dichloromethane; water pH=4.2; Product distribution / selectivity;

1: N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride With 1H-imidazole in dichloromethane T=10 - 15°C; 1 h; 2: (2S,3aS,7aS)-octahydroindole-2-carboxylic acid trimethylsilyl ester in dichloromethane T=10°C; 3 h; 3: tert-butylamine in dichloromethane T=10 - 40°C; 1 h; Product distribution / selectivity;

1: N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride With 1H-imidazole in dichloromethane T=-5 - 0°C; 1 h; 2: (2α,3aβ,7aβ)-octahydro-1H-indole-2-carboxylic acid in dichloromethane T=-5 - 25°C; 4.75 h; 3: tert-butylamine in dichloromethane T=10 - 40°C; 1 h; Product distribution / selectivity;