1-(4-乙酰基苯基)-2,2,2-三氟乙烷酮合成路线 (共 4 条)
反应条件
1: p-bromo-(2'-methyl-1',3'-dioxolan-2'-yl)-benzene With magnesium in tetrahydrofuran
Heating;
2: ethyl-α,α,α-trifluoroacetate T=-78°C;
3: With hydrogenchloride
T=20°C;
参考文献
Sasaki, Shigeru; Yamauchi, Takayasu; Kubo, Hajime; Kanai, Masatomi; Ishii, Akihiro; Higashiyama, Kimio
Tetrahedron Letters, 2005 , vol. 46, # 9 p. 1497 - 1500
反应条件
n-butyllithium
Yield given. Multistep reaction;
参考文献
Chen, Loomis S.; Chen, Grace J.; Tamborski, Christ
Journal of Organometallic Chemistry, 1983 , vol. 251, # 2 p. 139 - 148
反应条件
diethylzinc in hexane
T=20°C; 5 h;
参考文献
Sasaki, Shigeru; Yamauchi, Takayasu; Kubo, Hajime; Kanai, Masatomi; Ishii, Akihiro; Higashiyama, Kimio
Tetrahedron Letters, 2005 , vol. 46, # 9 p. 1497 - 1500
反应条件
1: diethylzinc With C58H44N2 in toluene
T=-20°C; 0.5 h; Inert atmosphere;
2: 1-(4-acetylphenyl)-2,2,2-trifluoroethanone in toluene
T=-40°C; Inert atmosphere; enantioselective reaction;
参考文献
Calvillo-Barahona, Mercedes; Cordovilla, Carlos; Genov, Miroslav N.; Martinez-Ilarduya, Jesus M.; Espinet, Pablo
Dalton Transactions, 2013 , vol. 42, # 40 p. 14576 - 14582