(S)-3-(4-氨基苯基)-2-(((苄氧基)羰基)氨基)丙酸叔丁酯合成路线 （共 2 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol
T=20°C; P=2585.81 - 3102.97 Torr; 3 h;
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2006/127584 A1, 2006 ;
Location in patent: Page/Page column 59; 69-71 ;
反应条件
1: Z-I-Ala-O-tBu With naphthalene; lithium; zinc(II) chloride in tetrahydrofuran
35 h;
2: para-amino-iodo-benzene With copper(I) bromide dimethylsulfide complex; tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium (0) in ethylene glycol dimethyl ether
T=-10 - 20°C; Negishi cross-coupling;
参考文献
Kruppa, Michael; Imperato, Giovanni; Koenig, Burkhard
Tetrahedron, 2006 , vol. 62, # 7 p. 1360 - 1364
