(S)-1,2,3,4-四氢-1-苯基异喹啉 D-(-)-酒石酸盐合成路线 （共 5 条）
反应条件
1: 1-phenyl-1,2,3,4-tetrahydroisoquinoline oxalate With sodium hydroxide in water; ethyl acetate T=20°C; pH=14; 2: (2S,3S)-2,3-dihydroxybutanedioic acid in water; ethyl acetate T=20°C; 1.08333 h; Product distribution / selectivity;
参考文献
Perlman, Nurit; Nidam, Tamar
Patent: US2008/91023 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
in water; ethyl acetate T=25 - 60°C; 1.5 h; Product distribution / selectivity;
参考文献
Perlman, Nurit; Nidam, Tamar
Patent: US2008/91023 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
1: sodium tetrahydroborate; iodine / tetrahydrofuran / 16 h / |Inert atmosphere; |Reflux 2: methanol / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 29 p. 10863 - 10869
反应条件
1.1: sodium hydroxide / toluene; water 2.1: pyridine / toluene / 20 - 80 °C 3.1: sodium hydride / tetrahydrofuran / 0.75 h / Reflux 3.2: 1.5 h / Reflux View Scheme
参考文献
ZAKLADY FARMACEUTYCZNE POLPHARMA SA; SZRAMKA, Roman; DRYGAS, Jersy; SZULC, Marcin
Patent: WO2011/86003 A1, 2011 ;
反应条件
sodium hydroxide in water; toluene
参考文献
WO2011/86003 A1, ;
Page/Page column 10 ;
