4-甲基-1-三苯甲基-1H-咪唑-2-甲醛合成路线 （共 2 条）
反应条件
1: 4-Methyl-1-(triphenylmethyl)-1H-imidazole With n-butyllithium in tetrahydrofuran; hexane
T=20°C; 1.5 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=0 - 20°C; 1 h;
参考文献
Magdolen, Peter; Vasella, Andrea
Helvetica Chimica Acta, 2005 , vol. 88, # 9 p. 2454 - 2469
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: 0.5 h / -78 - 20 °C
View Scheme
参考文献
ZENOBIA THERAPEUTICS, INC.; BOUNAUD, Pierre-Yves; NIENABER, Vicki; STEENSMA, Ruo, W.; LOWE, John, A., III
Patent: WO2012/178015 A2, 2012 ;
WO 2012/178015 A2
