乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
1: toluene / 4 h / Heating 2: diphenyl ether / 2 h / Heating View Scheme
参考文献
Bi, Yingzhi; Stoy, Patrick; Adam, Leonard; He, Bin; Krupinski, John; Normandin, Diane; Pongrac, Ron; Seliger, Laurie; Watson, Andrew; Macor, John E.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1577 - 1580
反应条件
1: 100 °C 2: diphenyl ether; various solvent(s) / 258 °C 3: POCl3 / Heating View Scheme
参考文献
Burke Jr.; Lim; Marquez; Li; Bolen; Stefanova; Horak
Journal of Medicinal Chemistry, 1993 , vol. 36, # 4 p. 425 - 432
反应条件
1: 1 h / Heating 2: various solvent(s) / 1 h / Heating View Scheme
参考文献
Golub, Andriy G.; Yakovenko, Olexander Ya.; Bdzhola, Volodymyr G.; Sapelkin, Vladislav M.; Zien, Piotr; Yarmoluk, Sergiy M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6443 - 6450
反应条件
2: trichlorophosphate View Scheme
参考文献
SENOMYS, INC.
Patent: US2011/245353 A1, 2011 ;
Title/Abstract Full Text Show Details
SENOMYX, INC.
Patent: US2012/41078 A1, 2012 ;
参考文献
Pharmacia and Upjohn Company
Patent: US6093732 A1, 2000 ;
反应条件
1: EtONa / ethanol 2: POCl3 View Scheme
参考文献
Palanki, Moorthy S.S.; Erdman, Paul E.; Manning, Anthony M.; Ow, Arnold; Ransone, Lynn J.; Spooner, Cheryl; Suto, Carla; Suto, Mark
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1645 - 1648
反应条件
potassium carbonate in ethanol 3.5 h; Heating;
参考文献
Holzer, Wolfgang; Schmid, Eva
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 4 p. 1341 - 1350
反应条件
1: Dowtherm A / 160 - 220 °C 2: POCl3 / 60 °C View Scheme
参考文献
Yu, Shu; He, Xiaohui; Ma, Chunrong; McKernan, Ruth; Cook, James M.
Medicinal Chemistry Research, 1999 , vol. 9, # 3 p. 186 - 202
反应条件
1: KOEt / ethanol / Heating 2: DMF; SOCl2 / Heating 3: H2; i-Pr2NEt / Pd(OH)2/C / ethanol View Scheme
参考文献
Tedder, Martina E.; Nie, Zhe; Margosiak, Stephen; Chu, Shaosong; Feher, Victoria A.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3165 - 3168
反应条件
1: EtONa / ethanol 2: POCl3 3: hydrazine View Scheme
参考文献
Palanki, Moorthy S.S.; Erdman, Paul E.; Manning, Anthony M.; Ow, Arnold; Ransone, Lynn J.; Spooner, Cheryl; Suto, Carla; Suto, Mark
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1645 - 1648
