乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
参考文献
Thomas; Adhikari, Airody Vasudeva; Telkar, Sandeep; Chowdhury, Imran H.; Mahmood, Riaz; Pal, Nishith K.; Row, Guru; Sumesh
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5283 - 5292
反应条件
1: toluene / Heating 2: diphenyl ether / 0.75 h / Heating 3: POCl3 / 2 h / Heating View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Keenan, Guy J.
Journal of Chemical Research, Miniprint, 1982 , # 6 p. 1726 - 1746
反应条件
1: diphenylether / 5 h / 100 °C / |Inert atmosphere 2: trichlorophosphate / 3 h / 80 °C View Scheme
参考文献
Zask; Gu; Albright; Du; Hogan; Levin; Chen; Killar; Sung; DiJoseph; Sharr; Roth; Skala; Jin; Cowling; Mohler; Barone; Black; March; Skotnicki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 8 p. 1487 - 1490
反应条件
1: pyridine / toluene / 2 h / Heating 2: diphenyl ether / 1 h / 250 °C 3: 0.995 g / thionyl chloride / 1 h / 80 °C View Scheme
参考文献
Goncalves, Victor; Brannigan, James A.; Whalley, David; Ansell, Keith H.; Saxty, Barbara; Holder, Anthony A.; Wilkinson, Anthony J.; Tate, Edward W.; Leatherbarrow, Robin J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3578 - 3582
反应条件
in acetonitrile 3 h; Heating;
参考文献
Sunder, Shyam; Peet, Norton P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 6 p. 1527 - 1529
反应条件
acetic acid 4 h; Reflux;
参考文献
Aghazadeh Tabrizi, Mojgan; Baraldi, Pier Giovanni; Saponaro, Giulia; Moorman, Allan R.; Romagnoli, Romeo; Preti, Delia; Baraldi, Stefania; Ruggiero, Emanuela; Tintori, Cristina; Tuccinardi, Tiziano; Vincenzi, Fabrizio; Borea, Pier Andrea; Varani, Katia
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4482 - 4496
反应条件
1: 2-picoline With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes T=-78 - -60°C; 0.5 h; Inert atmosphere; 2: diethyl 2-ethoxymethylenemalonate in tetrahydrofuran; hexanes T=-60 - -20°C; Inert atmosphere; 3: in xylenes 16 h; Reflux;
参考文献
Kuduk, Scott D.; Chang, Ronald K.; Di Marco, Christina N.; Pitts, Daniel R.; Greshock, Thomas J.; Ma, Lei; Wittmann, Marion; Seager, Matthew A.; Koeplinger, Kenneth A.; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T.; Ray, William J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4773 - 4780
反应条件
titanium tetrachloride in tetrahydrofuran Heating;
参考文献
Bissell
Synthesis, 1982 , vol. No. 10, p. 846 - 848
反应条件
1.1: sodium / ethanol / 9 h / 20 °C / |Inert atmosphere 2.1: trichlorophosphate / 1 h / 100 °C 3.1: zinc / tetrahydrofuran / 1 h / 60 °C 3.2: 23 h / 60 °C View Scheme
参考文献
Lopes, Alexandra Basilio; Miguez, Eduardo; Kuemmerle, Arthur Eugen; Rumjanek, Victor Marcos; Fraga, Carlos Alberto Manssour; Barreiro, Eliezer J.
Molecules, 2013 , vol. 18, # 10 p. 11683 - 11704
反应条件
1: Heating; 2: With trichlorophosphate
参考文献
Modh, Rahul P; Shah, Dhruvin; Chikhalia, Kishor H
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 10 p. 1318 - 1324
