乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
sodium ethanolate in ethanol T=20 - 90°C; 48 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; WANG, Tiansheng; HANZELKA, Brian; MUH, Ute; BEMIS, Guy; ZUCCOLA, Harmon, J.
Patent: WO2011/19405 A1, 2011 ;
Location in patent: Page/Page column 119 ;
WO 2011/019405 A1
反应条件
1: ethanolic sodium ethylate 2: aqueous H2SO4; aqueous H2O2 View Scheme
参考文献
Whitehead
Journal of the American Chemical Society, 1952 , vol. 74, p. 4267,4269
反应条件
Gould-Jacob reaction; 0.0666667 h; Irradiation;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 41, # 3 p. 650 - 652
反应条件
1: ethanol / Reflux 2: diphenylether / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1448 - 1452
反应条件
1: 87 percent / 3 h / Heating 2: 75 percent / various solvent(s) / 1.15 h / Heating View Scheme
参考文献
Golub, Andriy G.; Yakovenko, Olexander Ya.; Bdzhola, Volodymyr G.; Sapelkin, Vladislav M.; Zien, Piotr; Yarmoluk, Sergiy M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6443 - 6450
反应条件
Gould-Jacob reaction; 0.0708333 h; Irradiation;
参考文献
Dave, Chaitanya G.; Joshipura, Hardik M.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 3 p. 650 - 652
反应条件
1: ethanol / Reflux 2: diphenylether / Reflux 3: thionyl chloride / 17 h / Reflux View Scheme
参考文献
Zask; Gu; Albright; Du; Hogan; Levin; Chen; Killar; Sung; DiJoseph; Sharr; Roth; Skala; Jin; Cowling; Mohler; Barone; Black; March; Skotnicki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 8 p. 1487 - 1490
反应条件
1: EtONa / ethanol 2: POCl3 View Scheme
参考文献
Palanki, Moorthy S.S.; Erdman, Paul E.; Manning, Anthony M.; Ow, Arnold; Ransone, Lynn J.; Spooner, Cheryl; Suto, Carla; Suto, Mark
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1645 - 1648
反应条件
1: 92 percent / 1.33 h / 100 °C 2: 65 percent / diphenyl ether / 1 h / 250 °C View Scheme
参考文献
Leyva, Elisa; Monreal, Elena; Hernandez, Alma
Journal of Fluorine Chemistry, 1999 , vol. 94, # 1 p. 7 - 10
反应条件
1: sodium ethanolate / ethanol / 48 h / 20 - 90 °C 2: trichlorophosphate; N,N-dimethyl-aniline / benzene / 8 h / 90 °C / Inert atmosphere View Scheme
参考文献
Pawar; Burungale; Karale
Indian Journal of Heterocyclic Chemistry, 2010 , vol. 20, # 2 p. 133 - 136
