乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
1: 60 percent / diphenyl ether / 250 °C 2: 80 percent / SOCl2 View Scheme
参考文献
Warshakoon, Namal C.; Sheville, Justin; Bhatt, Ritu Tiku; Ji, Wei; Mendez-Andino, Jose L.; Meyers, Kenneth M.; Kim, Nick; Wos, John A.; Mitchell, Chrissy; Paris, Jennifer L.; Pinney, Beth B.; Reizes, Ofer; Hu, X. Eric
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5207 - 5211
反应条件
1: 2-methyl-2-thiopseudourea sulfate With ethanol; sodium ethanolate T=0°C; Inert atmosphere; 2: diethyl 2-ethoxymethylenemalonate in ethanol T=0 - 20°C; Inert atmosphere;
参考文献
Cho, Hidetsura; Nishimura, Yoshio; Yasui, Yoshizumi; Kobayashi, Satoshi; Yoshida, Shin-Ichiro; Kwona, Eunsang; Yamaguchi, Masahiko
Tetrahedron, 2011 , vol. 67, # 14 p. 2661 - 2669
参考文献
Todd; Fletcher; Tarbell
Journal of the American Chemical Society, 1943 , vol. 65, p. 350,352
反应条件
potassium hydroxide das basische Hydrojodid entsteht;
参考文献
Wheeler; Johnson; Johns
American Chemical Journal, 1907 , vol. 37, p. 396
反应条件
1: With sodium methylate in methanol Reflux; 2: With water; potassium hydroxide in methanol 2 h; Reflux; 3: With hydrogenchloride in methanol; water T=20°C; 2 h;
参考文献
MERCK SHARP and DOHME CORP.; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia; DANG, Qun
Patent: WO2013/40790 A1, 2013 ;
Location in patent: Page/Page column 33 ;
反应条件
1: 90 percent / 3 h / Heating 2: 80 percent / various solvent(s) / 1.15 h / Heating View Scheme
参考文献
Golub, Andriy G.; Yakovenko, Olexander Ya.; Bdzhola, Volodymyr G.; Sapelkin, Vladislav M.; Zien, Piotr; Yarmoluk, Sergiy M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6443 - 6450
反应条件
Gould-Jacob reaction; 0.075 h; Irradiation;
参考文献
Dave, Chaitanya G.; Joshipura, Hardik M.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 3 p. 650 - 652
反应条件
hydrogenchloride in ethanol; dichloromethane; sodium ethanolate; ethyl acetate
参考文献
Corvas International, Inc.
Patent: US5656645 A1, 1997 ;
US 5656645 A
反应条件
sodium ethanolate in ethanol T=20 - 60°C; 6.0833 h; Inert atmosphere;
参考文献
AstraZeneca AB
Patent: US2009/264401 A1, 2009 ;
Location in patent: Page/Page column 117 ;
参考文献
Corvas International, Inc.
Patent: US6011158 A1, 2000 ;
