乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
ethanol; sodium ethanolate Heating;
参考文献
Scott, James S.; Gill, Adrian L.; Godfrey, Linda; Groombridge, Sam D.; Rees, Amanda; Revill, John; Schofield, Paul; Soerme, Pernilla; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6756 - 6761
参考文献
Sawa et al.
Yakugaku Zasshi, 1947 , vol. 67, p. 204
Chem.Abstr., 1951 , p. 9063
反应条件
in diphenylether; ethanol T=132 - 270°C; 0.916667 h;
参考文献
PFIZER INC.
Patent: WO2005/21554 A1, 2005 ;
Location in patent: Page/Page column 94-95 ;
反应条件
1: toluene / Heating 2: diphenyl ether / 250 °C View Scheme
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
反应条件
1: EtONa / ethanol 2: POCl3 View Scheme
参考文献
Todd; Fletcher; Tarbell
Journal of the American Chemical Society, 1943 , vol. 65, p. 350,352
参考文献
Dainippon Pharmaceutical Co., Ltd.
Patent: US6372740 B1, 2002 ;
反应条件
dowtherm A in ethanol 0.5 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/14580 A1, 2006 ;
Location in patent: Page/Page column 38 ;
参考文献
SENOMYS, INC.
Patent: US2011/245353 A1, 2011 ;
Title/Abstract Full Text Show Details
SENOMYX, INC.
Patent: US2012/41078 A1, 2012 ;
反应条件
1: 2 h / 110 - 115 °C 2: various solvent(s) / 0.5 h / 250 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: 2 h / 120 - 130 °C 2: diphenyl ether / 1 h / Heating 3: K2CO3 / dimethylformamide / 10 h / 80 - 90 °C View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
