乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
参考文献
Justus Liebigs Annalen der Chemie, , vol. 297, p. 75
参考文献
Miknis, Greg; Lyssikatos, Joseph P.; Laird, Ellen; Tarlton, Eugene; Buckmelter, Alexandre J.; Ren, Li; Rast, Bryson; Schlacter, Stephen T.; Wenglowsky, Steven Mark
Patent: US2007/49603 A1, 2007 ;
Location in patent: Page/Page column 66 ;
US 20070049603 A1
反应条件
in acetic acid Heatingovernight;
参考文献
Anderson; Richardson
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 6 p. 1735 - 1737
反应条件
1.) 120 deg C, 1 h, 2.) Dowtherm A, reflux; Multistep reaction;
参考文献
Siim, Bronwyn G.; Atwell, Graham J.; Anderson, Robert F.; Wardman, Peter; Pullen, Susan M.; Wilson, William R.; Denny, William A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 9 p. 1381 - 1390
反应条件
1: sodium acetate / N,N-dimethyl-formamide / 18 h / 110 °C 2: trichlorophosphate / 1.5 h / 90 °C / Cooling with ice View Scheme
参考文献
Scott, James S.; Gill, Adrian L.; Godfrey, Linda; Groombridge, Sam D.; Rees, Amanda; Revill, John; Schofield, Paul; Soerme, Pernilla; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6756 - 6761
反应条件
1: in ethanol T=20°C; 19 h; Heating / reflux; 2: With acetic acid in ethanol 57 h; Heating / reflux;
参考文献
Novartis AG
Patent: EP1918291 A1, 2008 ;
Location in patent: Page/Page column 22 ;
参考文献
Beecham Group Limited
Patent: US4081545 A1, 1978 ;
反应条件
PPA in water; toluene
参考文献
Minnesota Mining and Manufacturing Company
Patent: US4301289 A1, 1981 ;
Title/Abstract Full Text Show Details
Minnesota Mining and Manufacturing Company
Patent: US4301291 A1, 1981 ;
反应条件
1: pyridine / toluene / 2 h / Heating 2: diphenyl ether / 1 h / 250 °C View Scheme
参考文献
Leyva, Elisa; Monreal, Elena; Hernandez, Alma
Journal of Fluorine Chemistry, 1999 , vol. 94, # 1 p. 7 - 10
反应条件
1: T=140°C; 1 h; Inert atmosphere; 2: in diphenylether 2 h; RefluxInert atmosphere;
参考文献
Goncalves, Victor; Brannigan, James A.; Whalley, David; Ansell, Keith H.; Saxty, Barbara; Holder, Anthony A.; Wilkinson, Anthony J.; Tate, Edward W.; Leatherbarrow, Robin J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3578 - 3582
