乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
in benzene 3.5 h; Reflux;
参考文献
GENZYME CORPORATION; TEICHER, Beverly A.; SCHMID, Steven M.
Patent: WO2012/15875 A1, 2012 ;
Location in patent: Page/Page column 44-45 ;
反应条件
1: 2 h / Heating 2: 74 percent / diphenyl ether / 0.5 h / Heating View Scheme
参考文献
Wang, C.-G.; Langer, T.; Kamath, P. G.; Gu, Z.-Q.; Skolnick, P.; Fryer, R. Ian
Journal of Medicinal Chemistry, 1995 , vol. 38, # 6 p. 950 - 957
参考文献
Chien, Ching-Ting; Shiu, Jin-Ruei; Chang, Chih-Ping; Hon, Yung-Son; Huang, Duo-Fong; Chou, Po-Ting; Liu, Ching-Yang; Chow, Tahsin J.
Journal of the Chinese Chemical Society, 2012 , vol. 59, # 3 p. 357 - 364
反应条件
T=140 - 150°C; 12 h;
参考文献
Bohn, Bernhard; Heinrich, Nicolaus; Vorbrueggen, Helmut
Heterocycles, 1994 , vol. 37, # 3 p. 1731 - 1746
参考文献
Popp,F.D. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 986
反应条件
sodium ethanolate in ethanol T=20°C; 96 h;
参考文献
Bonger, Kimberly M.; van den Berg, Richard J.B.H.N.; Heitman, Laura H.; IJzerman, Ad P.; Oosterom, Julia; Timmers, Cornelis M.; Overkleeft, Herman S.; van der Marel, Gijsbert A.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 4841 - 4856
反应条件
1.1: pyridine / toluene / 2 h / Heating 2.1: diphenyl ether / 1 h / 250 °C 2.2: 350 mg / thionyl chloride / 1 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6351 - 6363
反应条件
sodium acetate in DMF (N,N-dimethyl-formamide) T=110°C; 18 h; Product distribution / selectivity;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/42519 A1, 2005 ;
Location in patent: Page/Page column 48 ;
WO 2005/042519 A1
反应条件
sodium ethanolate in ethanol 1 h, reflux; 24 h, 4 deg C;
参考文献
Kristen, Helmut; Raddatz, Marianne
Zeitschrift fuer Chemie (Stuttgart, Germany), 1981 , vol. 21, # 3 p. 101
反应条件
1: toluene / Heating 2: diphenyl ether / 250 °C View Scheme
参考文献
De; Byers; Krogstad
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 315 - 320
