乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
1: toluene / Heating
2: diphenyl ether / 0.75 h / Heating
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Keenan, Guy J.
Journal of Chemical Research, Miniprint, 1982 , # 6 p. 1726 - 1746
反应条件
1: |Reflux
2: 250 °C / |Reflux
View Scheme
参考文献
Saxena, Anil K.; Roy, Kuldeep K.; Singh, Supriya; Vishnoi; Kumar, Anil; Kashyap, Vivek Kr.; Kremer, Laurent; Srivastava, Ranjana; Srivastava, Brahm S.
International Journal of Antimicrobial Agents, 2013 , vol. 42, # 1 p. 27 - 35
参考文献
Laboratorie Roger Bellon; Dainippon Pharmaceutical
Patent: US4292317 A1, 1981 ;
US 4292317 A
反应条件
1: 100 percent / 2 h / 120 - 130 °C
2: diphenyl ether / 1 h / Heating
View Scheme
参考文献
Hiltensperger, Georg; Jones, Nicola G.; Niedermeier, Sabine; Stich, August; Kaiser, Marcel; Jung, Jamin; Puhl, Sebastian; Damme, Alexander; Braunschweig, Holger; Meinel, Lorenz; Engstler, Markus; Holzgrabe, Ulrike
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2538 - 2548
反应条件
1: 100 percent / 2 h / 120 - 130 °C
2: diphenyl ether / 1 h / Heating
3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
View Scheme
参考文献
Podanyi, Benjamin; Kereszturi, Geza; Vasvari-Debreczy, Lelle; Chinoin, Istvan Hermecz; Toth, Gabor
Magnetic Resonance in Chemistry, 1996 , vol. 34, # 11 p. 972 - 978
反应条件
1.1: diphenylether / 4 h / |Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 125 °C
2.2: 4 h / 70 - 120 °C
View Scheme
参考文献
Vymed Corporation; SHETTY, B. Vithal
Patent: US2014/73631 A1, 2014 ;
反应条件
in diphenylether
T=90°C; 8 h; Reflux;
参考文献
HIGH POINT PHARMACEUTICALS, LLC; GADDAM, Bapu; POLISETTI, Dharma Rao; GUZEL, Mustafa; VICTORY, Samuel; KOSTURA, Matthew
Patent: WO2011/22216 A1, 2011 ;
Location in patent: Page/Page column 27-28 ;
WO 2011/022216 A1
反应条件
1: 100 - 120 °C
2: Eaton's reagent / 90 - 100 °C / |Inert atmosphere
View Scheme
参考文献
Golub, Andriy G.; Yakovenko, Olexander Ya.; Bdzhola, Volodymyr G.; Sapelkin, Vladislav M.; Zien, Piotr; Yarmoluk, Sergiy M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6443 - 6450
反应条件
1: 1 h / 110 - 120 °C
2: diphenyl ether / 0.5 h / 240 - 250 °C
View Scheme
参考文献
Podanyi, Benjamin; Kereszturi, Geza; Vasvari-Debreczy, Lelle; Chinoin, Istvan Hermecz; Toth, Gabor
Magnetic Resonance in Chemistry, 1996 , vol. 34, # 11 p. 972 - 978
反应条件
1: 2 h / 125 - 130 °C
2: diphenylether / 1 h / |Reflux
View Scheme
参考文献
Srivatava; Kumar
Oriental Journal of Chemistry, 2013 , vol. 29, # 2 p. 507 - 511
