乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
1: 67.8 percent / benzene / 3 h / Heating
2: 44 percent / Dowtherm A / 1 h / Heating
View Scheme
参考文献
Tonetti; Primofiore
Farmaco, Edizione Scientifica, 1980 , vol. 35, # 12 p. 1052 - 1058
反应条件
dowtherm A
0.75 h; Heating;
参考文献
Tonetti; Primofiore
Farmaco, Edizione Scientifica, 1980 , vol. 35, # 12 p. 1052 - 1058
反应条件
dowtherm A
1 h; Heating;
参考文献
Tonetti; Primofiore
Farmaco, Edizione Scientifica, 1980 , vol. 35, # 12 p. 1052 - 1058
反应条件
sodium
1.) xylene, benzene, overnight, 2.) xylene, benzene, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Donkor, Augustine; Prager, Rolf H.; Taylor, Max R.; Thompson, Malcolm J.
Australian Journal of Chemistry, 1992 , vol. 45, # 11 p. 1781 - 1789
反应条件
1: 2 h / 130 °C
2: 52 percent / NaH/oil / ethanol / 0.25 h
View Scheme
参考文献
Kazembe, Takawira, C.-G; Taylor, Deryck, A.
Tetrahedron, 1980 , vol. 36, # 88 p. 2125 - 2132
反应条件
1: (heating)
2: Heating
View Scheme
参考文献
Snyder,H.R.; Ebetino,F.R.
Journal of Heterocyclic Chemistry, 1966 , vol. 3, p. 202 - 205
参考文献
GLAXO GROUP LIMITED; GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.
Patent: WO2007/54296 A1, 2007 ;
Location in patent: Page/Page column 67 ;
反应条件
1: 49 percent / 4 h / 130 °C
2: 88 percent / diphenyl ether / 0.25 h / Heating
3: 90 percent / hydroxylamine hydrochloride, sodium acetate / aq. ethanol / 1 h / Heating
4: 90 percent / ethyl chloroformate, pyridine / CHCl3 / 48 h / Ambient temperature
View Scheme
参考文献
Tamura, Yasumitsu; Fujita, Masanobu; Chen, Ling Ching; Ueno, Kyoji; Kita, Yasuyuki
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 289 - 296
反应条件
1: With ammonium chloride in acetonitrile
2 h; Reflux;
2: With sodium hydrogencarbonate in water
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY; PATEL, Kanu, Maganbhai; SELBY, Thomas, Paul; SMITH, Brenton, Todd; TAGGI, Andrew, Edmund; KOVACS, Patrick, Ryan; PURI, Atul; PATZOLDT, William Louis
Patent: WO2012/33548 A2, 2012 ;
Location in patent: Page/Page column 96 ;
反应条件
1: With ammonium chloride in acetonitrile
2 h; Reflux;
2: With sodium hydrogencarbonate in water
3: With hydrogenchloride in water
pH=1 - 2;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY; KOVACS, Patrick, Ryan; PATEL, Kanu, Maganbhai; SELBY, Thomas, Paul; SMITH, Brenton, Todd; TAGGI, Andrew, Edmund
Patent: WO2011/31658 A1, 2011 ;
Location in patent: Page/Page column 81 ;
