乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
1: potassium hydroxide / |Heating
2: PPA / 2 h / 70 - 80 °C
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参考文献
Arava, Veera Reddy; Bandatmakuru, Sreenivasula Reddy
Synthesis (Germany), 2013 , vol. 45, # 8 art. no. SS-2013-Z0041-OP, p. 1039 - 1044
反应条件
1: ethanol / 4 h / 85 °C
2: Dowtherm™ A / 3 h / 250 °C
3: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C
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参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
2: hexane
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参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
in ethanol
T=0 - 20°C; 5 h; Heating / reflux;
参考文献
Shionogi and Co., Ltd.
Patent: EP1953145 A1, 2008 ;
Location in patent: Page/Page column 20 ;
反应条件
sodium ethanolate in ethanol; dichloromethane; water
参考文献
LUCKY LTD.
Patent: EP602589 A1, 1994 ;
反应条件
phosphorus trichoride
Behandeln des Reaktionsprodukts erst mit Wasser, dann mit Natronlauge;
参考文献
Michaelis; Remy
Chemische Berichte, 1907 , vol. 40, p. 1020
反应条件
potassium carbonate in ethanol
T=80°C; 16 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/23235 A1, 2008 ;
Location in patent: Page/Page column 30 ;
参考文献
Le Hao Dong; Coquelet; Bastide; Lebecq
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 119 - 124
反应条件
T=120°C; 3 h; Heating / reflux;
参考文献
Helicon Therapeutics, Inc.
Patent: US2008/306049 A1, 2008 ;
Location in patent: Page/Page column 36-37 ;
反应条件
in methanol
0.25 h; Ambient temperature;
参考文献
Arya, F.; Bouquant, J.; Chuche, J.
Synthesis, 1983 , # 11 p. 946 - 948
