乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
1.1: 4 h / 120 °C / |Inert atmosphere
1.2: 8 h / 260 °C / |Inert atmosphere
2.1: trichlorophosphate / 3 h / |Reflux; |Inert atmosphere
3.1: ammonia / water; isopropyl alcohol / 110 °C
View Scheme
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; TANG, Xiao Qing; KARANEWSKY, Donald S.; SERVANT, Guy; LI, Xiaodong; ZHANG, Feng; CHEN, Qing; ZHANG, Hong; DAVIS, Timothy; DARMOHUSODO, Vincent; WONG, Melissa; SELCHAU, Victor
Patent: WO2013/25560 A1, 2013 ;
反应条件
sodium hydroxide; PPA
参考文献
Riker Laboratories, Inc.
Patent: US4472405 A1, 1984 ;
反应条件
1: in diethyl ether
T=20°C;
2: in diphenylether
T=230 - 250°C; 1.5 h;
参考文献
TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB
Patent: WO2007/14926 A1, 2007 ;
Location in patent: Page/Page column 82-83 ;
反应条件
aluminum oxide; potassium carbonate
T=100°C; Michael addition; P=4137.29 Torr; 0.0833333 h; Microwave irradiationNeat (no solvent);
参考文献
Kim, Ki Won; Lee, Hee Jung; Jo, Jeong Im; Kwon, Tae Woo
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 5 p. 1155 - 1158
反应条件
sodium ethanolate in ethanol
24 h; Heating;
参考文献
Menichi, Gabriel; Hubert-Habart, Michel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 209 - 213
反应条件
sodium ethanolate in ethanol
24 h; Heating;
参考文献
Menichi, Gabriel; Hubert-Habart, Michel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 209 - 213
反应条件
sodium ethanolate in ethanol
24 h; Heating;
参考文献
Menichi, Gabriel; Hubert-Habart, Michel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 209 - 213
参考文献
Santilli,A.A. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 68 - 72
参考文献
Foster et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1327,1330
反应条件
in methanol
1 h; Ambient temperature;
参考文献
Coqueret, Xavier; Bourelle-Warginer, Francoise; Chuche, Josselin; Toupet, Loic
Bulletin de la Societe Chimique de France, 1987 , # 2 p. 365 - 371
