乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
1: 2 h / 110 - 115 °C
2: various solvent(s) / 0.5 h / 250 °C
3: POCl3 / 5 h / Heating
View Scheme
参考文献
Karolak-Wojciechowska, Janina; Lange, Jerzy; Ksiazek, Waldemar; Gniewosz, Malgorzata; Rump, Slawomir
Farmaco, 1998 , vol. 53, # 8-9 p. 579 - 585
反应条件
in acetic acid
6 h; Heating;
参考文献
Clayton, J. Peter; Rogers, Norman H.; Smith, Victoria J.; Stevenson, Robert; King, Trevor J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1347 - 1351
参考文献
Howden,M.E.H. et al.
Journal of the American Chemical Society, 1966 , vol. 88, p. 1732 - 1742
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Reynolds
American Chemical Journal, 1910 , vol. 44, p. 321
参考文献
Santilli,A.A. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 68 - 72
参考文献
Wheeler; Johns
American Chemical Journal, 1908 , vol. 40, p. 242
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Wheeler; Johnson; Johns
American Chemical Journal, 1907 , vol. 37, p. 396
参考文献
Johnson; Chi
Recueil des Travaux Chimiques des Pays-Bas, 1930 , vol. 49, p. 86,88
反应条件
sodium ethanolate in ethanol
Cyclization;
参考文献
Palanki, Moorthy S.S.; Erdman, Paul E.; Manning, Anthony M.; Ow, Arnold; Ransone, Lynn J.; Spooner, Cheryl; Suto, Carla; Suto, Mark
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1645 - 1648
反应条件
potassium ethanolate in ethanol
Heating;
参考文献
Tedder, Martina E.; Nie, Zhe; Margosiak, Stephen; Chu, Shaosong; Feher, Victoria A.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3165 - 3168
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
参考文献
Corelli; Massa; Stefancich; Artico; Panico; Simonetti
Farmaco, Edizione Scientifica, 1984 , vol. 39, # 2 p. 95 - 109
