乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
参考文献
Ballard; Johnson
Journal of the American Chemical Society, 1942 , vol. 64, p. 794,797
参考文献
Whitehead
Journal of the American Chemical Society, 1952 , vol. 74, p. 4267,4269
反应条件
(i) NaOEt, (ii) aq. HCl; Multistep reaction;
参考文献
Kristen; Hamann; Kitzig
Pharmazie, 1976 , vol. 31, # 8 p. 536 - 540
参考文献
Wheeler; Johnson; Johns
American Chemical Journal, 1907 , vol. 37, p. 396
参考文献
Hurd; Sherwood
Journal of Organic Chemistry, 1948 , vol. 13, p. 471,474
反应条件
diphenylether; biphenyl
T=150 - 160°C; Erhitzen des Reaktionsgemisches auf 245grad;
参考文献
Breslow et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1232,1236
反应条件
1: triethylamine / 1 h / 100 °C
2: Eaton's reagent / 90 - 100 °C / |Inert atmosphere
View Scheme
参考文献
Mistry, Shailesh N.; Valant, Celine; Sexton, Patrick M.; Capuano, Ben; Christopoulos, Arthur; Scammells, Peter J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5151 - 5172
反应条件
T=100°C; 3 h; Inert atmosphere;
参考文献
CLEAVE BIOSCIENCES, INC.; ZHOU, Han-Jie; WUSTROW, David
Patent: WO2014/66506 A2, 2014 ;
Location in patent: Page/Page column 95 ;
反应条件
1: 110 °C
View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
反应条件
T=200 - 225°C; 0.166667 h;
参考文献
Nagahara; Kawano; Sasaoka; Ukawa; Hirama; Takada; Cottam; Robins
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 1 p. 239 - 243
