乙氧基甲叉丙二酸二乙酯合成路线 （共 444 条）
反应条件
1: 4 h / 120 °C 2: POCl3, (i-Pr)2NEt / xylene / 14 h / Heating View Scheme
参考文献
Zask; Gu; Albright; Du; Hogan; Levin; Chen; Killar; Sung; DiJoseph; Sharr; Roth; Skala; Jin; Cowling; Mohler; Barone; Black; March; Skotnicki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 8 p. 1487 - 1490
反应条件
1: |Heating 2: thionyl chloride / |Heating View Scheme
参考文献
Ferreira, Vitor F.; Leal, Katia Z.; Lindgren, Eric B.; De Oliveira, Mara R.P.; De Souza, Maria Celia B.V.; Vasconcelos, Thatyana R.A.; Wardell, James L.; Wardell, Solange M.S.V.; Yoneda, Julliane D.
Journal of Molecular Structure, 2013 , vol. 1051, p. 299 - 309
参考文献
Bazhin, Denis N.; Kudyakova, Yulia S.; Burgart, Yanina V.; Saloutin, Victor I.
Tetrahedron Letters, 2012 , vol. 53, # 15 p. 1961 - 1963
反应条件
T=140 - 150°C; 12 h;
参考文献
Bohn, Bernhard; Heinrich, Nicolaus; Vorbrueggen, Helmut
Heterocycles, 1994 , vol. 37, # 3 p. 1731 - 1746
反应条件
hydrogenchloride in ethanol; water; ethyl acetate
参考文献
Corvas International, Inc.
Patent: US5656645 A1, 1997 ;
US 5656645 A
反应条件
in ethanol T=120°C; 15 h; Microwave irradiation;
参考文献
MERCK SHARP andamp; DOHME CORP.; KEENAN, Kevin, A.; NORTHRUP, Alan, B.
Patent: WO2010/65384 A1, 2010 ;
Location in patent: Page/Page column 30; 31 ;
反应条件
1: ethanolic sodium ethylate 2: aqueous H2SO4; aqueous H2O2 View Scheme
参考文献
Ballard; Johnson
Journal of the American Chemical Society, 1942 , vol. 64, p. 794,797
反应条件
sodium methylate in methanol 4 h;
参考文献
Scott, James S.; Gill, Adrian L.; Godfrey, Linda; Groombridge, Sam D.; Rees, Amanda; Revill, John; Schofield, Paul; Soerme, Pernilla; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6756 - 6761
参考文献
Ballard; Johnson
Journal of the American Chemical Society, 1942 , vol. 64, p. 794,797
反应条件
toluene-4-sulfonic acid in xylene T=140°C; Heating / reflux;
参考文献
MERCK PATENT GMBH
Patent: WO2006/125530 A1, 2006 ;
Location in patent: Page/Page column 51-52 ;
