1: [3H]-Indoleacetic acid With HATU in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: 1-methyl-piperazine in N,N-dimethyl-formamide
4 h;
参考文献
MYREXIS, INC.; KUMAR, Dange Vijay; SLATTUM, Paul M.; YAGER, Kraig M.; SHENDEROVICH, Mark D.; TANGALLAPALLY, Rajendra; KIM, Se-Ho
Patent: WO2012/177782 A1, 2012 ;
Location in patent: Page/Page column 99-100 ;
WO 2012/177782 A1
potassium carbonate in N,N-dimethyl-formamide
T=130°C; 8 h; RefluxGreen chemistry;
参考文献
Jiang, Xinglong; Tiwari, Ashish; Thompson, Maethonia; Chen, Zhihong; Cleary, Thomas P.; Lee, Thomas B. K.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 604 - 608
potassium carbonate in N,N-dimethyl-formamide
T=130°C; 6 h; RefluxGreen chemistry;
参考文献
Jiang, Xinglong; Tiwari, Ashish; Thompson, Maethonia; Chen, Zhihong; Cleary, Thomas P.; Lee, Thomas B. K.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 604 - 608
1: 99 percent / SOCl2 / 12 h / -78 - 25 °C
2: 92 percent / NaH / tetrahydrofuran / 0 °C
View Scheme
参考文献
Atta-ur-Rahman; Sultana, Mumtaz; Hassan, Iltifat; Hasan, Naeem M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2093 - 2096
