反应条件
1: p-toluenesulfonic acid
2: p-toluenesulfonic acid / acetone / 23 °C
3: 1.) MeLi / 1.) THF, -78 deg C
4: toluene / Irradiation
5: 1.) OsO4, NaIO4, 2.) NaBH4 / 1.) THF,H2O, 2.) ethanol
6: pyridine
7: dimethylformamide
8: CH3CO3H, NaHCO3 / CH2Cl2
9: 1.) LDA / 1.) THF, 0 deg C, 15 min
10: pyridine / 23 °C
11: Li, NH3 / tetrahydrofuran / -78 °C
12: 2.) K2CO3 / 1.) 1,2-dichloroethane, 70 deg C, 24 h, 2.) MeOH, 0 deg C
13: 1.) LiN(SiMe3)2 / 1.) dioxane
14: 80percent HOAc
15: Na2CO3, KOH / ethanol; tetrahydrofuran
View Scheme
参考文献
Keck, Gary E.; Kachensky, David F.; Enholm, Eric J.
Journal of Organic Chemistry, 1984 , vol. 49, # 8 p. 1462 - 1464
