1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
potassium carbonate in acetone Heating;
参考文献
Majumdar, Krishna C.; Jana, Gour H.
Journal of Organic Chemistry, 1997 , vol. 62, # 5 p. 1506 - 1508
反应条件
tert.-butyl lithium; copper (I) cyanide 1.) pentane, THF-Et2O 3:1 a) -95 deg C, 6 min b) -90 deg C, 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wenkert, Ernest; Angell, E. Charles; Ferreira, Vitor F.; Michelotti, Enrique L.; Piettre, Serge R.; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 12 p. 2343 - 2351
反应条件
1: 40 percent / lithium hydride / dimethylsulfoxide / 45 deg C, 5 h; 25 deg C, 10 h 2: m-chloroperoxybenzoic acid / CH2Cl2 / 17 h / 25 °C 3: 67 percent / BF3*OEt2 / CH2Cl2 / 21 h / 25 °C View Scheme
参考文献
Sun, Jerry S.; Geiser, Andrew H.; Frydman, Benjamin
Tetrahedron Letters, 1998 , vol. 39, # 45 p. 8221 - 8224
反应条件
potassium hydroxide; tetrabutylammomium bromide in toluene 72 h; Heating;
参考文献
Reisch,J.; Salehi-Artimani,R.A.
Monatshefte fuer Chemie, 1985 , vol. 116, p. 1099
反应条件
1: 85 percent / LDA / tetrahydrofuran / 1.) -78 deg C, 3 h, 2.) -78 deg C to r.t., 12 h 2: 75 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -100 deg C, 1 h, 2.) -85 deg C, 1 h View Scheme
参考文献
Weyerstahl, Peter; Schenk, Anja; Marschall, Helga
Liebigs Annalen, 1995 , # 10 p. 1849 - 1854
反应条件
n-butyllithium 1.) Et2O, -70 deg C, 30 min, 2.) Et2O, a.) -70 deg C, 2 h, b.) 25 deg C, overnight; Yield given. Multistep reaction;
参考文献
Ismail, Zeinhom Mostafa; Hoffmann, Martin R.
Heterocycles, 1986 , vol. 24, # 2 p. 325 - 327
反应条件
indium; methyllithium 1.) 1,4-dioxane, 2.) 0 deg C, 30 min; room temperature, 2 h, 3.) 1,4-dioxane, 0 deg C, 1 h, room temperature, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Araki, Shuki; Jin, Shun-Ji; Butsugan, Yasuo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 5 p. 549 - 552
反应条件
in N,N-dimethyl-formamide T=120 - 160°C; 19 h;
参考文献
Coxon, Geoffrey D.; Furman, Brian L.; Harvey, Alan L.; McTavish, John; Mooney, Mark H.; Arastoo, Mahmoud; Kennedy, Alan R.; Tettey, Justice M.; Waigh, Roger D.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3457 - 3463
反应条件
in N,N-dimethyl-formamide 12 h; Reflux;
参考文献
SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; LETALLEC, Jean-Philippe; MARCINIAK, Gilbert; RONAN, Baptiste; VIVET, Bertrand
Patent: WO2013/190510 A2, 2013 ;
Location in patent: Page/Page column 122-123 ;
反应条件
in N,N-dimethyl-formamide
参考文献
Kennewell, Peter D.; Matharu, Saroop S.; Taylor, John B.; Sammes, Peter G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2542 - 2548
