1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
1: propargyl alcohol With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1.5 h; Inert atmosphere; 2: With copper(l) iodide in tetrahydrofuran; hexane T=0°C; 0.5 h; Inert atmosphere; 3: prenyl bromide in tetrahydrofuran; hexane T=0 - 20°C; Inert atmosphere;
参考文献
Hodgson, David M.; Arif, Tanzeel
Organic Letters, 2010 , vol. 12, # 18 p. 4204 - 4207
反应条件
1: 1.) HMPA, n-BuLi / 1.) THF, hexane, -30 deg C, 30 min, 2.) room temperature, 20 h 2: TMSCl / methanol / 1 h / Ambient temperature View Scheme
参考文献
Owada, Yufu; Matsuo, Takeshi; Iwasawa, Nobuharu
Tetrahedron, 1997 , vol. 53, # 32 p. 11069 - 11086
反应条件
indium; triphenylphosphine; lithium chloride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
Journal of Organic Chemistry, , vol. 67, # 23 p. 8265 - 8268
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; copper(l) chloride in dichloromethane; water T=20°C; 23 h; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 57, # 7 p. 2188 - 2192
参考文献
Smith III, Amos B.; Hirschmann, Ralph F.; Nittoli, Thomas; Sprengeler, Paul
Patent: US2002/123635 A1, 2002 ;
反应条件
lithium diisopropyl amide in tetrahydrofuran; hexane
2 h; Ambient temperature;
参考文献
Rawal; Singh; Dufour; Michoud
Journal of Organic Chemistry, 1993 , vol. 58, # 27 p. 7718 - 7727
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 6 h, 2.) 25 deg C, 18 h
2: 65 percent / N-chlorosuccinimide, silver nitrate / acetonitrile / 1 h / 25 °C
View Scheme
参考文献
Padwa,A.; Rodriguez,A.; Tohidi,M.
Journal of the American Chemical Society, 1983 , vol. 105, p. 933
反应条件
1.1: dimethylformamide
2.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C
3.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.2: tetrahydrofuran; hexane / 2 h / -78 - 0 °C
4.1: LiHMDS / tetrahydrofuran; hexane / 3 h
View Scheme
参考文献
Orita, Akihiro; Yoshioka, Naonori; Struwe, Petra; Braier, Arnold; Beckmann, Anke; Otera, Junzo
Chemistry--A European Journal, 1999 , vol. 5, # 4 p. 1355 - 1363
反应条件
1: 82 percent / 50percent NaOH, tetrabutylammonium bromide / tetrahydrofuran / 18 h / Ambient temperature
2: 55 percent / FSO3H / liquid sulphur dioxide / 0.25 h / -78 °C
3: 75 percent / Dibal-H / toluene / 0.25 h / 100 °C
View Scheme
参考文献
Janssen, Cornelus G. M.; Godefroi, Erik F.
Journal of Organic Chemistry, 1984 , vol. 49, # 19 p. 3600 - 3603
反应条件
potassium hydroxide in methanol
T=0°C;
参考文献
TAKARA BIO INC.
Patent: EP1702912 A1, 2006 ;
Location in patent: Page/Page column 19 ;
