1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
1: dimethyl 2-(prop-2-ynyl)malonate With sodium hydride in tetrahydrofuran 0.0833333 h; 2: prenyl bromide in tetrahydrofuran T=23°C; 6 h;
参考文献
Munoz, Ma. Paz; Mendez, Maria; Nevado, Cristina; Cardenas, Diego J.; Echavarren, Antonio M.
Synthesis, 2003 , # 18 p. 2898 - 2902
反应条件
1: potassium carbonate / acetone 2: sodium hydride / diethyl ether View Scheme
参考文献
Lykakis, Ioannis N.; Psyllaki, Androniki; Stratakis, Manolis
Journal of the American Chemical Society, 2011 , vol. 133, # 27 p. 10426 - 10429
反应条件
n-butyllithium in tetrahydrofuran; hexane -78 deg C, 1 h; -78 deg C, 1 h then -50 deg C, 3 h;
参考文献
Fuji, Kaoru; Kawabata, Takeo; Ohmori, Toshiumi; Shang, Muhong; Node, Manabu
Heterocycles, 1998 , vol. 47, # 2 p. 951 - 964
反应条件
tert.-butyl lithium; copper (I) cyanide 1.) pentane, THF-Et2O 3:1 a) -95 deg C, 6 min b) -90 deg C, 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wenkert, Ernest; Angell, E. Charles; Ferreira, Vitor F.; Michelotti, Enrique L.; Piettre, Serge R.; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 12 p. 2343 - 2351
反应条件
ammonium chloride; zinc in tetrahydrofuran; water appropriate alkyltin chloride is added to THF/H2O mixt. with excess of zinc powder, appropriate allyl bromide is added dropwise under stirring within 5 min, mixt. is stirred for 30 min; extn. (petroleum ether), separated org. layer is washed (aq. NaCl), drying (MgSO4), solvent is removed, distn., mixt. of isomers 3-methyl-1-buten-3-yltributyltin and 2-methyl-2-butenyltributyltin ratio 40:60; total yield 62percent;
参考文献
Gyldenfeldt, Friederike von; Marton, Daniele; Tagliavini, Giuseppe
Organometallics, 1994 , vol. 13, p. 906 - 913
反应条件
1: potassium carbonate 3: 2-chloro-2-methyl-butene-(3); hydrogen chloride View Scheme
参考文献
Claisen
Journal fuer Praktische Chemie (Leipzig), 1922 , vol. <2> 105, p. 72
Chemische Berichte, 1925 , vol. 58, p. 279 Anm. 15
反应条件
chromium dichloride; lithium iodide in tetrahydrofuran T=55°C; Hiyama-Nozaki reaction; 3 h;
参考文献
Journal of Organic Chemistry, , vol. 67, # 7 p. 1975 - 1981
反应条件
chromium dichloride; lithium iodide in tetrahydrofuran T=55°C; Hiyama-Nozaki reaction; 3 h;
参考文献
Journal of Organic Chemistry, , vol. 67, # 7 p. 1975 - 1981
反应条件
1: 97 percent 2: 70 percent / NaCl, H2O / dimethylsulfoxide / 12 h / 180 °C 3: 86 percent / LAH / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Curran, Dennis P.; Yu, Hosung; Liu, Hongtao
Tetrahedron, 1994 , vol. 50, # 25 p. 7343 - 7366
参考文献
Bird, Paul; Eames, Jason; Fallis, Alex G.; Jones, Ray V. H.; Roddis, Marc; Sturino, Claudio F.; O'Sullivan, Susan; Warren, Stuart; Westwell, Martin S.; Worrall, Julia
Tetrahedron Letters, 1995 , vol. 36, # 11 p. 1909 - 1912
