1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
allyl zinc bromide in tetrahydrofuran
T=65°C; MechanismProduct distribution;
参考文献
Godschalx, J. P.; Stille, J. K.
Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1905 - 1908
参考文献
Julia,M.; Descoins,C.
Bulletin de la Societe Chimique de France, 1970 , p. 1822 - 1833
参考文献
Godschalx, J. P.; Stille, J. K.
Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1905 - 1908
反应条件
1: 57 percent / NaH / toluene
2: 78 percent / Et3N, DMAP / CH2Cl2
3: 60 percent / (o-tol)3P, Et3N / Pd(OAc)2 / toluene / 24 h / 100 °C
4: 89 percent / K2CO3 / methanol
View Scheme
参考文献
Bates; Gabel
Tetrahedron Letters, 1993 , vol. 34, # 22 p. 3547 - 3550
反应条件
sodium hydride
1.) toluene, 60 - 65 deg C, 3.5 h, 2.) 35 deg C, 72 h.; Yield given. Multistep reaction;
参考文献
Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M.
Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106
反应条件
sodium hydroxide
1.) water, 22 degC, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kitagawa; Fukuda; Yoshihara; Yamahara; Yoshikawa
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 1 p. 352 - 355
反应条件
1: 1.) Mg; 2.) m-ClC6H4CO3H / 1.) ether; 2.)
2: 14 percent / LiNEt2 / diethyl ether; hexane / 1 h / Heating
View Scheme
参考文献
Apparu, Marcel; Barrelle, Michel
Bulletin de la Societe Chimique de France, 1983 , vol. 2, # 3-4 p. 83 - 86
反应条件
1: 27 percent / 10percent NaOH / 5 h / 20 °C
2: 31 percent / Et3N; tri-o-tolyl phosphine / Pd(OAc)2 / toluene / 20 h / 100 °C
3: 78 percent / 10percent KOH / H2O; methanol / 1 h / Heating
View Scheme
参考文献
Uto, Yoshihiro; Hirata, Akihiko; Fujita, Tomoya; Takubo, Syunsuke; Nagasawa, Hideko; Hori, Hitoshi
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2355 - 2357
反应条件
sodium acetate in acetic acid
1 h;
参考文献
Achenbach; Franke; Renner
Archiv der Pharmazie, 1985 , vol. 318, # 12 p. 1147 - 1150
反应条件
lithium hydroxide; 1-n-butyl-3-methylimidazolium tetrafluoroborate
T=20°C; 5 h;
参考文献
Kryshtal; Zhdankina; Zlotin
Russian Chemical Bulletin, 2004 , vol. 53, # 3 p. 652 - 658
