1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
Multistep reaction.;
参考文献
Maiti, Arup; Cuendet, Muriel; Croy, Vicki L.; Endringer, Denise C.; Pezzuto, John M.; Cushman, Mark
Journal of Medicinal Chemistry, 2007 , vol. 50, # 12 p. 2799 - 2806
反应条件
1: 22 percent / 10 percent aq. KOH
2: 95 percent / K2CO3 / acetone
View Scheme
参考文献
Suh; Lee; Kim; Han
Bioorganic and medicinal chemistry letters, 1999 , vol. 9, # 10 p. 1433 - 1436
反应条件
potassium carbonate in N,N-dimethyl-formamide
0.5 h; Reflux;
参考文献
Epifano, Francesco; Genovese, Salvatore; James Squires; Gray, Matthew A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3130 - 3135
反应条件
1: 1.) butyllithium / 1.) -40 to -20 deg C, 2.) -70 deg C
2: 75 percent / HgO/HgCl2 / diethyl ether
View Scheme
参考文献
Bokel, H. H.; Hoppmann, A.; Weyerstahl, P.
Tetrahedron, 1980 , vol. 36, # 5 p. 651 - 654
反应条件
1: 100 percent / ethanol / 12 h / Ambient temperature
2: 527.6 mg / NaCl / dimethylsulfoxide; H2O / 5 h / 170 °C
View Scheme
参考文献
Colonge,J. et al.
Bulletin de la Societe Chimique de France, 1965 , p. 2733 - 2738
反应条件
1: 40 g / ethanol / 1.) 15 deg C, 6 h, 2.) reflux, 0.5 h
2: 16 g / sodium hydroxide / H2O
3: 11.7 g / pyridine / H2O / 2 h / Heating
4: 18.4 g / lithium aluminium hydride / diethyl ether / 1.) 0 deg C, 2.) reflux, 1 h
5: 1.) toluene-p-sulphonyl chloride,pyridine, 2.) sodium iodide / 1.) 24 h, 2.) acetone, reflux, 16 h
6: 24 g
7: water, silver oxide / 15 °C
8: 150 - 160 °C
View Scheme
参考文献
Cocker, Wesley; Geraghty, Niall W. A.; McMurry, T. Brian H.; Shannon, Patrick V. R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 10 p. 2245 - 2254
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 6.5 h;
参考文献
Harayama, Takashi; Katsuno, Keiko; Nishita, Yoshitaka; Fujii, Masako; Abe, Hitoshi; Takeuchi, Yasuo
Heterocycles, 2001 , vol. 54, # 1 p. 319 - 328
反应条件
1: 1.) NaH / hexamethylphosphoric acid triamide / 1 h / Ambient temperature; 2.) 30 min
2: K2CO3 / acetone
View Scheme
参考文献
Borges-Del-Castillo, Juan; mArtinez-Martir, Ana I.; Rodriguez-Luis, Francisco; Rodriguez Ubis, Juan C.; Vazquez-Bueno, Purificacion
Phytochemistry (Elsevier), 1984 , vol. 23, # 4 p. 859 - 862
反应条件
hydrogenchloride; potassium carbonate
Yield given. Multistep reaction;
参考文献
Harayama; Katsuno; Nishita; Fujii
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1550 - 1552
反应条件
1: 1.) Li, 2.) TBACu(I)Br2 / 1.) ethyl ether, -15 deg C, 2 h, 2.) ethyl ether, -70 deg C
2: 23.8 percent / TBABH4, rose bengal, TBABr/I, oxygen / CHCl3 / 1.75 h / Irradiation
View Scheme
参考文献
Baeckstroem, Peter; Bjoerkling, Fredrik; Hoegberg, Hans-Erik; Norin, Torbjoern
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 9 p. 779 - 782
