1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
lithium in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Uchida, Minoru; Nakagawa, Kazuyuki; Negishi, Tsutomu; Asano, Shoji; Mori, Kenji
Agricultural and Biological Chemistry, 1981 , vol. 45, # 2 p. 369 - 372
反应条件
1: 1.) Li, 2.) TBACu(I)Br2 / 1.) ethyl ether, -15 deg C, 2 h, 2.) ethyl ether, -70 deg C
2: 10.9 percent / TBABH4, rose bengal, TBABr/I, oxygen / CHCl3 / 1.75 h / Irradiation
View Scheme
参考文献
Baeckstroem, Peter; Bjoerkling, Fredrik; Hoegberg, Hans-Erik; Norin, Torbjoern
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 9 p. 779 - 782
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: water / dimethyl sulfoxide / 2 h / Reflux
3.1: bismuth trifluoromethanesulphonate / nitromethane / 2 h / Reflux; Inert atmosphere
View Scheme
参考文献
Cacciuttolo, Bastien; Poulain-Martini, Sophie; Dunach, Elisabet
European Journal of Organic Chemistry, 2011 , # 20-21 p. 3710 - 3714
反应条件
potassium carbonate in acetone
12 h; Heating;
参考文献
Okely, Martyn H.; Grundon, Michael F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 897 - 899
反应条件
1: potassium iodide, potassium carbonate
2: 1.) BuLi
3: 74 percent / sodium borohydride
4: 71 percent / sodium hydride / dimethylformamide / 0.5 h / 50 °C
View Scheme
参考文献
Buss, Antony D.; Mason, Ralph; Warren, Stuart
Tetrahedron Letters, 1983 , vol. 24, # 47 p. 5293 - 5296
反应条件
1: 89 percent / 1.) BuLi; 2.) HMPA / tetrahydrofuran; hexane / -70 - -50 °C
2: DIBAL / CH2Cl2 / 2 h / -78 °C
View Scheme
参考文献
Oppolzer, Wolfgang; Darcel, Christophe; Rochet, Patrick; Rosset, Stephane; Brabander, Jef De
Helvetica Chimica Acta, 1997 , vol. 80, # 5 p. 1319 - 1337
反应条件
(i) LDA, (ii) /BRN= 1420778/, CuI, (iii) /BRN= 102415/; Multistep reaction;
参考文献
Katzenellenbogen,J.A.; L Crumrine,A.
Journal of the American Chemical Society, 1976 , vol. 98, # 16 p. 4925 - 4935
反应条件
1: 1.) NaOH / 1.) acetone, reflux, 1 h, 2.) acetone, reflux, 24 h
2: 75.8 percent / 85percent H3PO4, P2O5 / benzene / 20 h / Heating
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
反应条件
aluminium trichloride; zinc in tetrahydrofuran
T=20°C;
参考文献
Keraenen, Mark D.; Eilbracht, Peter
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 12 p. 1688 - 1690
反应条件
1: 1.) tBuLi, 2.) HMPA / 1.) THF, pentane, -78 deg C, 0.25 h, 0 deg C, 0.5 h, 2.) room temp., 16 h
2: 82 percent / 2N HCl / tetrahydrofuran / 4 h / 45 °C
View Scheme
参考文献
Boeckman, Robert K.; Bruza, Kenneth J.
Tetrahedron, 1981 , vol. 37, # 23 p. 3997 - 4006
