1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
参考文献
Cazes,B.; Julia,S.
Bulletin de la Societe Chimique de France, 1977 , p. 925 - 930
反应条件
1: 2-methylpropanoic acid methyl ester With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C; 1.5 h; Inert atmosphere;
2: prenyl bromide in tetrahydrofuran; hexane
T=-78°C; 1.5 h; Inert atmosphere;
参考文献
Friedrich, Julian; Doerrich, Steffen; Berkefeld, Andre; Kraft, Philip; Tacke, Reinhold
Organometallics, 2014 , vol. 33, # 3 p. 796 - 803
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether; hexane
1.) 20 min, 2.) reflux, 15 min; Yield given. Yields of byproduct given;
参考文献
Leal, Walter Soares; Kuwahara, Yasumasa; Suzuki, Takahisa; Nakao, Hiroshi
Agricultural and Biological Chemistry, 1989 , vol. 53, # 12 p. 3279 - 3284
反应条件
1: sodium ethylate; ethanol
2: methylurea; ethanolic sodium ethylate
View Scheme
参考文献
Allais; Mathieu
Annales Pharmaceutiques Francaises, 1951 , vol. 9, p. 275,281
反应条件
1: LDA / tetrahydrofuran / -78 - 25 °C
2: NaOH / ethanol; H2O / 20 h / 78 °C
3: 74 percent / HCOOH, H2SO4 / 96 h / 25 °C
4: 98 percent / LiAlH4 / diethyl ether / 1 h / 25 °C
5: 90 percent / PBr3, pyridine / diethyl ether / 2 h / -78 - 25 °C
View Scheme
参考文献
Froehner, Wolfgang; Reddy, Kethiri R.; Knoelker, Hans-Joachim
Arkivoc, 2012 , vol. 2012, # 3 p. 330 - 342
反应条件
1: With lithium bromide
T=-25°C;
2: With nitric acid; acetic anhydride in acetic acid
T=0°C; 12 h;
3: With tin(ll) chloride in ethanol
T=70°C; 7 h; Further stages.;
参考文献
Ciszewski, James T.; Xie, Baohan; Cao, Changsheng; Odom, Aaron L.
Dalton Transactions, 2003 , # 22 p. 4226 - 4227
反应条件
1: 1.) NaH, (iPr)2NH, 2.) n-BuLi / 1.) THF, 0 deg C and reflux, 15 min, 2.) THF, HMPA, 0 deg C, 15 min and 35 deg C 30 min, 3.) THF, HMPA, 0 deg C and 3 h, 25 deg C
2: 91 percent / LiAlH4 / diethyl ether / 10 h / 0 °C
3: Et3N / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Becker; Haddad
Tetrahedron, 1993 , vol. 49, # 4 p. 947 - 964
反应条件
1: dimethylformamide
2: HCl / CH2Cl2 / -78 °C
3: H2O, Et3N / dioxane
View Scheme
参考文献
Grob,C.A.; Waldner,A.
Helvetica Chimica Acta, 1979 , vol. 62, p. 1854 - 1865
反应条件
sec.-butyllithium
1.) ether, cyclohexane, -78 deg C, 30 min, 2.) -78 deg C up to room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Yoshinori; Yatagai, Hidetaka; Saito, Yoshikazu; Maruyama, Kazuhiro
Journal of Organic Chemistry, 1984 , vol. 49, # 6 p. 1096 - 1104
反应条件
sec.-butyllithium
1.) ether, cyclohexane, -78 deg C, 30 min, 2.) -78 deg C up to room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Yoshinori; Yatagai, Hidetaka; Saito, Yoshikazu; Maruyama, Kazuhiro
Journal of Organic Chemistry, 1984 , vol. 49, # 6 p. 1096 - 1104
