1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
sodium methylate
1) MeOH 2) reflux, 3h;
参考文献
Roy, D; Khanna, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 7 p. 583 - 586
反应条件
1.1: NaH / tetrahydrofuran / 0.17 h / 0 °C
1.2: tetrahydrofuran / 6 h / 20 °C
2.1: 1.32 g / K2CO3 / H2O / 2 h / 80 °C
3.1: 85 percent / DIBAL-H / CH2Cl2 / 2 h / -78 °C
View Scheme
参考文献
Tong, Rongbiao; McDonald, Frank E.; Fang, Xikui; Hardcastle, Kenneth I.
Synthesis, 2007 , # 15 p. 2337 - 2342
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
4 h; Heating;
参考文献
Dammertz; Reimann
Archiv der Pharmazie, 1982 , vol. 315, # 1 p. 27 - 32
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Paquette, Leo A.; Kinney, William A.
Tetrahedron Letters, 1982 , vol. 23, # 2 p. 131 - 134
反应条件
1: 91 percent / NaH / dimethylformamide
2: 6 percent Na-Hg, Na2HPO4 / methanol / 0.5 h / Ambient temperature
View Scheme
参考文献
Paquette, Leo A.; Kinney, William A.
Tetrahedron Letters, 1982 , vol. 23, # 2 p. 131 - 134
反应条件
1: 91 percent / NaH / dimethylformamide
2: 6 percent Na-Hg, Na2HPO4 / methanol / 0.5 h / Ambient temperature
View Scheme
参考文献
Paquette, Leo A.; Kinney, William A.
Tetrahedron Letters, 1982 , vol. 23, # 2 p. 131 - 134
反应条件
1: 1.) NaH / 1.) DMF
2: 1.) NaHPO4, 6percent natrium amalgame, 2.) p-toluenesulfonic acid / 1.) methanol, 40 min, 2.) ethanol, water, 11 h, reflux
View Scheme
参考文献
Paquette, Leo A.; Kinney, William A.
Tetrahedron Letters, 1982 , vol. 23, # 2 p. 131 - 134
反应条件
1: 1.) NaH / 1.) DMF
2: 87 percent / PPTS / acetone / 4 h / Heating
View Scheme
参考文献
Kinney, William A.; Crouse, Gary D.; Paquette, Leo A.
Journal of Organic Chemistry, 1983 , vol. 48, # 25 p. 4986 - 5000
反应条件
zinc in tetrahydrofuran
4 h; Ambient temperature;
参考文献
Araki, Shuki; Jin, Shun-Ji; Idou, Yoshiyuki; Butsugan, Yasuo
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 6 p. 1736 - 1738
反应条件
zinc in tetrahydrofuran
4 h; Further byproducts given;
参考文献
Kapoor, N. K.; Gupta, R. B.; Khanna, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 3 p. 189 - 191
