1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
copper(l) iodide; n-butyllithium in tetrahydrofuran
T=-60°C; 1 h;
参考文献
Ishihara, Takashi; Yamana, Masayuki; Ando, Teiichi
Tetrahedron Letters, 1983 , vol. 24, # 50 p. 5657 - 5660
反应条件
1: 1.) n-BuLi / 1.) hexane, ether, room temperature, overnight, 2.) xylene, 70-80 deg C, 3 h
2: oxalic acid / methanol; H2O / 2 h
View Scheme
参考文献
Matsuyama, Shigeru; Kuwahara, Yasumasa; Nakamura, Shigeko; Suzuki, Takahisa
Agricultural and Biological Chemistry, 1991 , vol. 55, # 5 p. 1333 - 1341
反应条件
1: 58 percent / NaH / toluene / 1 h / 20 °C
2: 96 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 4 h / Heating
3: 93 percent / Et3N; tri(o-tolyl)phosphine / Pd(OAc)2 / toluene / 20 h / Heating
4: 74 percent / KOH / H2O; methanol / 3 h / Heating
View Scheme
参考文献
Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728
反应条件
1: 27 percent / 10percent NaOH / 5 h / 20 °C
2: 31 percent / Et3N; tri-o-tolyl phosphine / Pd(OAc)2 / toluene / 20 h / 100 °C
3: 78 percent / 10percent KOH / H2O; methanol / 1 h / Heating
View Scheme
参考文献
Uto, Yoshihiro; Hirata, Akihiko; Fujita, Tomoya; Takubo, Syunsuke; Nagasawa, Hideko; Hori, Hitoshi
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2355 - 2357
反应条件
1: 96 percent / K2CO3 / acetone / 15 h / 50 °C
2: 70 percent / MCPBA / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Demyttenaere, Jan; Vervisch, Stijn; Debenedetti, Silvia; Coussio, Jorge; Maes, Dominick; De Kimpe, Norbert
Synthesis, 2004 , # 11 p. 1844 - 1848
反应条件
n-butyllithium
1) diethyl ether, 1 h, reflux, 2) 1 h, 40 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Asakawa, Yoshinori; Kondo, Keiko; Tori, Motoo; Hashimoto, Toshihiro; Ogawa, Shunichi
Phytochemistry (Elsevier), 1991 , vol. 30, # 1 p. 219 - 234
反应条件
copper(l) iodide; sec.-butyllithium in tetrahydrofuran
1.) 0 deg C then r.t., 2 h; 2.) -70 deg C;
参考文献
Bouzbouz; Kirschleger
Synthesis, 1994 , # 7 p. 714 - 718
反应条件
potassium hydroxide in N,N-dimethyl-formamide
T=60 - 70°C; 2 h;
参考文献
Kahovcova; Romanuk
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 6 p. 1413 - 1424
反应条件
sodium hydroxide; tetrabutylammomium bromide
15 h; Ambient temperature;
参考文献
Bertrand, M. P.; Riggi, I. De; Lesueur, C.; Gastaldi, S.; Nouguier, R.; et al.
Journal of Organic Chemistry, 1995 , vol. 60, # 19 p. 6040 - 6045
反应条件
1: dimethylformamide
2: 80 percent / 50percent NaOH, tetrabutylammonium bromide
View Scheme
参考文献
Janssen, Cornelus G. M.; Hendriks, Adrianus H. M.; Godefroi, Erik F.
Recueil: Journal of the Royal Netherlands Chemical Society, 1984 , vol. 103, # 7-8 p. 220 - 224
