1-溴-3-甲基-2-丁烯合成路线 （共 689 条）
反应条件
1: 1-bromo-4-methyl-2-nitrobenzene With phenyllithium in tetrahydrofuran
T=-78°C; 0.0833333 h;
2: prenyl bromide With N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran
T=-78°C; 3 h;
参考文献
Pirrung, Michael C.; Liu, Yufa; Deng, Liu; Halstead, Diana K.; Li, Zhitao; May, John F.; Wedel, Michael; Austin, Darrell A.; Webster, Nicholas J. G.
Journal of the American Chemical Society, 2005 , vol. 127, # 13 p. 4609 - 4624
反应条件
lithium hydride in dimethyl sulfoxide
45 deg C, 5 h; 25 deg C, 10 h;
参考文献
Sun, Jerry S.; Geiser, Andrew H.; Frydman, Benjamin
Tetrahedron Letters, 1998 , vol. 39, # 45 p. 8221 - 8224
反应条件
potassium carbonate in acetone
1 h; Reflux;
参考文献
Epifano, Francesco; Genovese, Salvatore; James Squires; Gray, Matthew A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3130 - 3135
反应条件
diethyl ether
T=0°C;
参考文献
Fieser
Journal of the American Chemical Society, 1927 , vol. 49, p. 857
Journal of the American Chemical Society, 1928 , vol. 50, p. 447
参考文献
Cooke
Australian Journal of Scientific Research, Series A: Physical Sciences, 1950 , vol. 3, p. 481,484,485
参考文献
Fieser
Journal of the American Chemical Society, 1926 , vol. 48, p. 3202,3206
Journal of the American Chemical Society, 1927 , vol. 49, p. 858,861
反应条件
tetraethylammonium iodide in various solvent(s)
T=20°C; 1.5 h;
参考文献
Perez-Victoria; Conseil; Maitrejean; Comte; Barron; Di Pietro; Castanys; Gamarro
Antimicrobial Agents and Chemotherapy, 2001 , vol. 45, # 2 p. 439 - 446
反应条件
1: 7 percent / K2CO3 / methanol / 8 h / Ambient temperature
2: 57 percent / Dowex 50 / methanol / 24 h / 40 °C
View Scheme
参考文献
Fukai, Toshio; Nomura, Taro
Heterocycles, 1992 , vol. 34, # 6 p. 1213 - 1225
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 2 h / 0 - 25 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 25 °C / Inert atmosphere
View Scheme
参考文献
Placzek, Andrew T.; Hougland, James L.; Gibbs, Richard A.
Organic Letters, 2012 , vol. 14, # 16 p. 4038 - 4041
反应条件
diethyl ether
Erhitzen des Reaktionsprodukts in Xylol;
参考文献
Kitahara; Funamizu
Bulletin of the Chemical Society of Japan, 1958 , vol. 31, p. 782
